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Browse our Lamin A/C Proteins (LMNA)

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Lamin A/C Proteins (LMNA)
On www.antibodies-online.com are 11 Lamin A/C (LMNA) Proteins from 6 different suppliers available. Additionally we are shipping Lamin A/C Antibodies (391) and Lamin A/C Kits (25) and many more products for this protein. A total of 443 Lamin A/C products are currently listed.
Synonyms:
74/76, 2459, cb948, CDCD1, CDDC, CG6944, CMD1A, CMT2B1, D5, Dhe, Dm, Dm(0), Dm0, Dm1, Dm2, Dmel\\CG6944, DmLamin, Dmo, Dm[[0]], Dm[[1]], Dm[[2]], Dm[[mit]], Dm[[o]], EMD2, fk66d12, FPL, FPLD, FPLD2, HGPS, IDC, jf27, l(2)04643, l(2)25Ec, l(2)gdh-7, l(2)gdh7, l(2)jf27, lam, Lam(Dm0), lamDm0, lamDm[[0]], Lam Dm[[0]], LamDm[[o]], lamin, Lamin-A, lamin-L(III)-like, lamin Dm0, lamin Dm[[0]], Lam[[Dm0]], LDP1, LFP, LGMD1B, LMN1, lmna-A, LMNC, LMNL1, misg, nlam, PRO1, wu:fk66d12
list all proteins Gene Name GeneID UniProt
LMNA 16905 P48678
LMNA 4000 P02545
LMNA 60374 P48679

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Lamin A/C Proteins (LMNA) by Origin

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Top referenced Lamin A/C Proteins

  1. Human Lamin A/C Protein expressed in Wheat germ - ABIN1309507 : Chen, Lin, Chow, Lee: Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells. in Proteomics 2011 (PubMed)
    Show all 2 references for ABIN1309507

More Proteins for Lamin A/C Interaction Partners

Fruit Fly (Drosophila melanogaster) Lamin A/C (LMNA) interaction partners

  1. The loss of lamin-B (show LMNB1 Proteins) leads to systemic inflammation and aging.

  2. nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin

  3. of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C

  4. Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA).

  5. Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.

  6. Lamin mutation is associated with neuromuscular defects and premature aging.

  7. prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B (show LMNB1 Proteins) envelope.

  8. Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis.

  9. The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila.

  10. Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal

Zebrafish Lamin A/C (LMNA) interaction partners

  1. results have important implications for understanding the tissue-specific regulation and functions of the lamin A gene

  2. The induction of embryonic senescence and laminopathies in zebrafish harboring disturbed expressions of the lamin A gene, is described.

Mouse (Murine) Lamin A/C (LMNA) interaction partners

  1. changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin (show EMD Proteins), also impact gene regulation and lineage differentiation in early embryos.

  2. administration of the exon 11 ASO reduced lamin A expression in wild-type mice and progerin expression in an HGPS mouse model.

  3. stabilization of perinuclear actin strengthens the transient interactions of lamin A with chromatin

  4. It was found that the lamin A protein expressed in mouse ear cartilage cells is shorter than protein expressed in mouse skin. This difference in protein length could be caused by differential cleavage in the cells of skin and ear cartilage tissues

  5. Annexin, lamin, and vimentin (show VIM Proteins) were identified as universal dystrophic markers

  6. These results identify SNX6 (show SNX6 Proteins) as a key regulator of lamin A synthesis and incorporation into the nuclear envelope.

  7. loss of Lmna under malignant conditions may, to a limited extent, enhance polyp size indicating that A-type lamins may regulate cell proliferation in the transformed GI epithelium

  8. The results presented in this work indicate that the detrimental effects of lamin A expression were less than anticipated in the brain, even after 90 weeks of transgenic expression.

  9. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.

  10. Results suggest that lamin A/C is critical for proper structural and functional development of the sperm acrosome and head shape.

Human Lamin A/C (LMNA) interaction partners

  1. Disruption of PCNA (show PCNA Proteins)-lamins A/C interactions by prelamin A induces DNA replication fork stalling

  2. the LMNA lipodystrophy mutations that we examined did not lead to prelamin A accumulation

  3. Suggest that an increased ventilatory response during exercise might reveal a preclinical manifestation of dilated cardiomyopathy in LMNA mutation carriers.

  4. Promoter hypermethylation is a mechanism for lamin A/C silencing in a subset of neuroblastoma (show ARHGEF16 Proteins) cells.

  5. Desmin, Lamin A/C, MMP9, and histone H4 were upregulated in the placental villi of women experiencing early pregnancy loss.

  6. Novel lamin A/C mutation (V445E) with a sudden death form of familial left ventricular non-compaction. The reduced sodium current in mutant LMNA may account for the advent of malignant ventricular arrhythmias. The altered structures of three beta sheets and side chains may partially explain the aggregation of lamin A/C protein (show HNRNPC Proteins) subjacent to the nuclear envelope.

  7. we identified a nonsense mutation expected to affect the LTD of LMNA in a 4-generation family with AF. This discovery expands the mutation spectrum of LMNA and indicates the importance of LMNA in AF.

  8. we describe two MADA (show AMPD1 Proteins) patients with progressive skeletal changes, absent breast development, and cataract in addition to the classical MAD phenotype. Both patients were found to be homozygous for the Ala529Val mutation of the LMNA gene.

  9. Variant c.513+45T>G in the LMNA gene is new intronic splicing mutation which is responsible for progressive cardiac conduction defects and variable myopathy.

  10. Cardiac involvement as a consequence of LMNA mutations generally has a more aggressive natural history than other forms of non-ischemic dilated cardiomyopathy. A high index of suspicion and prompt referral for genetic testing are essential for appropriate therapeutic management

Pig (Porcine) Lamin A/C (LMNA) interaction partners

  1. Both anti-lamin A/C and anti-lamin B (show LMNB1 Proteins) staining were clearly present in all embryonic stages.

  2. A study mapping the location of procine lamin type A to chromosome 4q is presented.

Xenopus laevis Lamin A/C (LMNA) interaction partners

  1. These results indicate that thyroid hormone (show PTH Proteins)-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.

  2. LIII filaments appear identical to the endogenous lamina, whereas lamin B2 (show LMNB2 Proteins) assembles into filaments that are organized less precisely; Lamin A induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope

Lamin A/C (LMNA) Protein Profile

Protein Summary

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Alternative names and synonyms associated with Lamin A/C (LMNA)

  • Lamin (Lam)
  • lamin A (lmna)
  • lamin A/C (LMNA)
  • lamin B3 (lmnb3)
  • lamin A/C (lmna)
  • lamin A (Lmna)
  • lamin A/C (Lmna)
  • 74/76 protein
  • 2459 protein
  • cb948 protein
  • CDCD1 protein
  • CDDC protein
  • CG6944 protein
  • CMD1A protein
  • CMT2B1 protein
  • D5 protein
  • Dhe protein
  • Dm protein
  • Dm(0) protein
  • Dm0 protein
  • Dm1 protein
  • Dm2 protein
  • Dmel\\CG6944 protein
  • DmLamin protein
  • Dmo protein
  • Dm[[0]] protein
  • Dm[[1]] protein
  • Dm[[2]] protein
  • Dm[[mit]] protein
  • Dm[[o]] protein
  • EMD2 protein
  • fk66d12 protein
  • FPL protein
  • FPLD protein
  • FPLD2 protein
  • HGPS protein
  • IDC protein
  • jf27 protein
  • l(2)04643 protein
  • l(2)25Ec protein
  • l(2)gdh-7 protein
  • l(2)gdh7 protein
  • l(2)jf27 protein
  • lam protein
  • Lam(Dm0) protein
  • lamDm0 protein
  • lamDm[[0]] protein
  • Lam Dm[[0]] protein
  • LamDm[[o]] protein
  • lamin protein
  • Lamin-A protein
  • lamin-L(III)-like protein
  • lamin Dm0 protein
  • lamin Dm[[0]] protein
  • Lam[[Dm0]] protein
  • LDP1 protein
  • LFP protein
  • LGMD1B protein
  • LMN1 protein
  • lmna-A protein
  • LMNC protein
  • LMNL1 protein
  • misg protein
  • nlam protein
  • PRO1 protein
  • wu:fk66d12 protein

Protein level used designations for Lamin A/C Proteins (LMNA)

B-type lamin , CG6944-PA , CG6944-PB , CG6944-PC , Lam-PA , Lam-PB , Lam-PC , Lamin-B , LaminDm , LaminDm0 , alpha-Lamin , intermediate filament-like lamina , lamin , lamin A , lamin B , lamin D , lamin D[[0]] , lamin D[[m]]0 , lamin D[[o]] , lamin Dm0 , lamin Dm[[0]] , lamin Dmo , lethal(2)25Ec , misguided , misrouted , n-lamin , nuclear lamin , prelamin-A/C , lamin B3 , lamin A/C , lamin LIII , lamin-A/C-like , lamin C , lamin-A/C , 70 kDa lamin , lamin A/C-like 1 , renal carcinoma antigen NY-REN-32 , lamin C2 , lamin-A

GENE ID SPECIES
33782 Drosophila melanogaster
195815 Danio rerio
457385 Pan troglodytes
719414 Macaca mulatta
733537 Xenopus (Silurana) tropicalis
733973 Xenopus (Silurana) tropicalis
100401580 Callithrix jacchus
100603145 Nomascus leucogenys
16905 Mus musculus
4000 Homo sapiens
60374 Rattus norvegicus
480124 Canis lupus familiaris
404144 Bos taurus
101107924 Ovis aries
100126859 Sus scrofa
373673 Xenopus laevis
415464 Gallus gallus
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