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|Antigen||NLR Family, Apoptosis Inhibitory Protein (NAIP) Antibodies|
|Conjugate||This NAIP antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-NAIP AntibodyTarget Details NAIP Application Details Handling Images
|Specificity||This antibody detects NAIP at C-term.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human|
|Purification||Peptide affinity chromatography|
|Immunogen||NAIP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.|
Target Details NAIPProduct Details anti-NAIP Antibody Application Details Handling Images back to top
|Alternative Name||NAIP (NAIP Antibody Abstract)|
|Background||Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy (1,2). Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR), these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO (4), suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported (5).Synonyms: BIRC1, Baculoviral IAP repeat-containing protein 1|
Application DetailsProduct Details anti-NAIP Antibody Target Details NAIP Handling Images back to top
ELISA. Western blot: 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-NAIP Antibody Target Details NAIP Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|