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The acidic domain of SET bound directly to the CTD of p53 (show TP53 ELISA Kits), and expression of CREB-binding protein (CBP (show CREBBP ELISA Kits)), which acetylates the p53 (show TP53 ELISA Kits) CTD, prevented SET binding to wild-type but not acetylation-deficient p53 (show TP53 ELISA Kits), further indicating that SET binds specifically to the unacetylated p53 (show TP53 ELISA Kits) CTD.
Overexpression of SET-Nup214 (show NUP214 ELISA Kits) in HeLa cells leads to the formation of similar nuclear bodies that recruit CRM1 (show XPO1 ELISA Kits), export cargo proteins, and certain nucleoporins and concomitantly affect nuclear protein (show RDBP ELISA Kits) and poly(A)(+) RNA export.
Molecular chaperone (show HSP90AA1 ELISA Kits) SET-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression.
Our findings suggested the oncogenic role of SET and the adverse prognostic value of SET overexpression in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)). This alteration defines a subgroup of HCC (show FAM126A ELISA Kits) patients who could benefit from SET antagonists, such as EMQA.
This review summarizes and discusses the general mechanisms of H3K4 methylation, and how the six main enzymes from the SET/MLL (show MLL ELISA Kits) family (responsible for H3K4me1/me2 (show CELSR1 ELISA Kits)/me3 (show ME3 ELISA Kits)) function in hematopoiesis and in hematologic malignancies. [review]
identification of the oncoprotein SET as a major cellular factor whose binding with p53 (show TP53 ELISA Kits) is dependent on C-terminal domain acetylation status
Data indicate that SET protein as a direct target of microRNA miR (show MLXIP ELISA Kits)-125b, and the downregulation of SET, observed during tumor migration, was affected by the overexpression of miR125b.
significance of SET/I2PP2A-mediated PP2A and non-PP2A pathways in polycystic ovary syndrome
Data show that downregulating proto-oncogene (show RAB1A ELISA Kits) protein Akt (p-Akt (show AKT1 ELISA Kits)) by inhibiting PP2A (show PPP2R4 ELISA Kits) inhibitor SET-mediated protein phosphatase 2A (PP2A (show PPP2R4 ELISA Kits)) inactivation determined the pro-apoptotic effects of EMQA and paclitaxel combination treatment.
Data suggest a critical role for the I2PP2A protein (SET)-protein phosphatase-2A (PP2A) signaling axis in Pten protein (Pten) deficient castration resistant prostate cancer (CRPC) progression.
The presence of full-length SET in the neuronal cytoplasm is sufficient to impair PP2A methylation and activity, leading to tau hyperphosphorylation.
SET/PP2A system regulates testosterone production in ovarian follicles in vitro.
SET played a positive role in regulating ovarian androgen biosynthesis by enhancing the transcription of steroidogenic enzymes CYP17A1 (show CYP17A1 ELISA Kits) and HSD3B2 (show HSD3B2 ELISA Kits), which maybe contribute to the hyperandrogenism in polycystic ovary syndrome
study found SET, a putative oncogene (show RAB1A ELISA Kits) was significantly downregulated in a bisphenol A dose-dependent manner; from gene network analysis, SET is predicted to communicate with other genes including CYP17 (show CYP17A1 ELISA Kits), which is involved in biosynthesis and metabolism of sex-hormones
Our results suggest that the increased I(2)(PP2A) may trigger apoptosis by p53 (show TP53 ELISA Kits) upregulation, but due to simultaneous activation of Akt (show AKT1 ELISA Kits), the neurons are aborted from the apoptotic pathway.
SET is an important regulator of chromosome condensation/decondensation and that disruption of the MCPH1 (show MCPH1 ELISA Kits)-SET interaction might be important for the pathogenesis of primary microcephaly
By a novel molecular mechanism, apolipoprotein (apo)E/peptide enhances protein phosphatase 2A (PP2A) activity within a cell by binding/forming a complex with SET, reducing the amount of SET available to inhibit PP2A, signaling, and inflammatory response.
These studies indicated that the TAF (show TAF8 ELISA Kits)-Ialpha promoter is under the control of Sp1 (show SP1 ELISA Kits).(TAF (show TAF8 ELISA Kits)-Ialpha )
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 2A inhibitor 2-like
, HLA-DR-associated protein II
, SET translocation (myeloid leukemia-associated)
, Template-Activating Factor-I, chromatin remodelling factor
, inhibitor of granzyme A-activated DNase
, inhibitor-2 of protein phosphatase-2A
, phosphatase 2A inhibitor I2PP2A
, protein SET
, protein phosphatase type 2A inhibitor
, SET translocation
, template-activating factor I
, liver regeneration-related protein LRRGR00002