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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Antibodies|
|Conjugate||This TNFRSF10A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-TNFRSF10A AntibodyTarget Details TNFRSF10A Application Details Handling Images
|Specificity||This antibody detects endogenous levels of DR4 protein. (region surrounding Asp430)|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen|
|Purity||> 95 % pure by SDS-PAGE|
Target Details TNFRSF10AProduct Details anti-TNFRSF10A Antibody Application Details Handling Images back to top
|Alternative Name||CD261 / TRAILR1 (TNFRSF10A Antibody Abstract)|
|Background||Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which, includes FAS antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the death domain, that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including FAS, DR2 (or TRUNDD), DR3 (Death Receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli.Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A|
|Molecular Weight||approx. 50 kDa|
|Research Area||Signaling, Apoptosis/Necrosis|
|Pathways||Apoptosis, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Handling Images back to top
ELISA: 1: 000approx. 1: 5000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||DO NOT FREEZE!|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
ImagesProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Handling back to top