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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||163 Antibodies|
|Functional Studies (Func)||26 Antibodies|
|Immunochromatography (IC)||6 Antibodies|
|Immunocytochemistry (ICC)||60 Antibodies|
|Immunofluorescence (IF)||30 Antibodies|
|Immunohistochemistry (IHC)||9 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||9 Antibodies|
|Immunoprecipitation (IP)||41 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Neutralization (Neut)||23 Antibodies|
|Western Blotting (WB)||126 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Antibodies|
|Epitope||Extracellular Domain Alternatives|
|Conjugate||This TNFRSF10A antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunoprecipitation (IP)
|Supplier||Log in to see|
Product Details anti-TNFRSF10A AntibodyTarget Details TNFRSF10A Application Details Handling Images
|Specificity||This antibody is specific for Human Death Receptor 4 (DR4/CD261).|
|Purification||Affinity Chromatography on Protein A|
|Immunogen||Fusion protein containing the extracellular region of CD261 (DR4). Spleen cells from immunised F1 hybrid mice were fused with cells of the SP2/0-Ag14 myeloma cell line|
Target Details TNFRSF10AProduct Details anti-TNFRSF10A Antibody Application Details Handling Images back to top
|Alternative Name||CD261 / TRAILR1 (TNFRSF10A Antibody Abstract)|
|Background||DR4 is a type I transmembrane protein of 468 amino acids, which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety of tumour-derived cell lines. DR4 plays a role in inducing cell death. The binding of TRAIL to DR4 triggers the activation of pro-caspases 8 and 10, leading to apoptosis.Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A|
|Research Area||Signaling, Apoptosis/Necrosis|
Application DetailsProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Handling Images back to top
Flow Cytometry: 1/50 - 1/100, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Images back to top
|Buffer||PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
|Expiry Date||12 months|
ImagesProduct Details anti-TNFRSF10A Antibody Target Details TNFRSF10A Application Details Handling back to top