|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) Antibodies|
|Epitope||AA 249-263, Intracellular Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TNFRSF10D antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-TNFRSF10D AntibodyTarget Details TNFRSF10D Application Details Handling Images
|Specificity||DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.|
|Purification||Affinity Chromatography purified via peptide column|
|Immunogen||Human DcR2 (Intracellular Domain) Peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.|
Target Details TNFRSF10DProduct Details anti-TNFRSF10D Antibody Application Details Handling Images back to top
|Alternative Name||CD264 / TRAILR4 (TNFRSF10D Antibody Abstract)|
|Background||Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D|
|Research Area||Apoptosis/Necrosis, Signaling|
Application DetailsProduct Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Handling Images back to top
ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details Images back to top
|Buffer||PBS containing 0.02 % Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|