|Application / Reactivity||Rat (Rattus)||Mouse (Murine)||Human|
|ELISA||2 Antibodies||2 Antibodies||61 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies||2 Antibodies|
|Immunofluorescence (IF)||1 Antibodies||1 Antibodies||3 Antibodies|
|Immunohistochemistry (IHC)||2 Antibodies||2 Antibodies||30 Antibodies|
|Western Blotting (WB)||1 Antibodies||4 Antibodies|
|Flow Cytometry (FACS)||42 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||1 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D) Antibodies|
|Epitope||AA 249-263, Intracellular Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TNFRSF10D antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF10D AntibodyTarget Details TNFRSF10D Application Details Handling References for anti-TNFRSF10D Antibody (ABIN499724) Images
|Specificity||DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.|
|Purification||Affinity Chromatography purified via peptide column|
|Immunogen||Human DcR2 (Intracellular Domain) Peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.|
Target Details TNFRSF10DProduct Details anti-TNFRSF10D Antibody Application Details Handling References for anti-TNFRSF10D Antibody (ABIN499724) Images back to top
|Alternative Name||CD264 / TRAILR4 (TNFRSF10D Antibody Abstract)|
|Background||Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D|
|Research Area||Signaling, Apoptosis/Necrosis|
Application DetailsProduct Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Handling References for anti-TNFRSF10D Antibody (ABIN499724) Images back to top
ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details References for anti-TNFRSF10D Antibody (ABIN499724) Images back to top
|Buffer||PBS containing 0.02 % Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-TNFRSF10D Antibody (ABIN499724)Product Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details Handling Images back to top
Pan, Ni, Yu et al.: "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling." in: FEBS letters, Vol. 424, Issue 1-2, pp. 41-5, 1998 (PubMed).
Degli-Esposti, Dougall, Smolak et al.: "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain." in: Immunity, Vol. 7, Issue 6, pp. 813-20, 1998 (PubMed).
Marsters, Sheridan, Pitti et al.: "A novel receptor for Apo2L/TRAIL contains a truncated death domain." in: Current biology : CB, Vol. 7, Issue 12, pp. 1003-6, 1998 (PubMed).
Sheridan, Marsters, Pitti et al.: "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 818-21, 1997 (PubMed).
Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 815-8, 1997 (PubMed).
Pan, ORourke, Chinnaiyan et al.: "The receptor for the cytotoxic ligand TRAIL." in: Science (New York, N.Y.), Vol. 276, Issue 5309, pp. 111-3, 1997 (PubMed).
ImagesProduct Details anti-TNFRSF10D Antibody Target Details TNFRSF10D Application Details Handling References for anti-TNFRSF10D Antibody (ABIN499724) back to top