anti-Human TNFRSF12A antibody for Blocking Reagent

Recommended TNFRSF12A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
  • CD266
  • FN14
  • TWEAKR
  • AI255180
  • C87282
  • Fn14
  • HPIP
  • TWEAK-R
  • TweakR
  • tumor necrosis factor receptor superfamily, member 12A
  • tumor necrosis factor receptor superfamily, member 12a
  • TNFRSF12A
  • Tnfrsf12a
Reactivity
Human
93
59
30
3
3
2
2
2
2
1
1
1
Host
Mouse
51
41
8
3
Clonality
Monoclonal
Conjugate
This TNFRSF12A antibody is un-conjugated
11
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunofluorescence (IF), ELISA
54
48
20
17
15
14
13
12
3
3
1
1
1
1
1
1
1
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Catalog No. ABIN2666428
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General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
Reactivity Human
(93), (59), (30), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Mouse
(51), (41), (8), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF12A antibody is un-conjugated
(11), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Immunofluorescence (IF), ELISA
(54), (48), (20), (17), (15), (14), (13), (12), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-TNFRSF12A Antibody

Target Details TNFRSF12A Application Details Handling ProductDetails: References for anti-TNFRSF12A antibody (ABIN2666428) Images
Brand LEAF™
Purification The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level

Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.

Clone ITEM-1
Isotype IgG1 kappa

Target Details TNFRSF12A

Product Details anti-TNFRSF12A Antibody Application Details Handling ProductDetails: References for anti-TNFRSF12A antibody (ABIN2666428) Images back to top
Antigen
Alternative Name CD266 (TNFRSF12A Antibody Abstract)
Background TWEAK receptor is also known as fibroblast growth factor inducible 14 kD protein (Fn14) or CD266. It is a 14 kD transmembrane protein that is expressed on a variety of tissue types. This receptor binds TWEAK and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The TWEAK receptor is rapidly induced during liver regeneration and m play a role in hepatocyte growth. TWEAK receptor engagement can induce cell death and may play a role in inflammation. The ITEM-1 antibody is useful for flow cytometric analysis, induction of tumor cells apoptosis or necrotic cell death, enhancing endothelial cell proliferation, and immunohistochemistry on frozen tissues.
Pathways Apoptosis, Regulation of Cell Size

Application Details

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling ProductDetails: References for anti-TNFRSF12A antibody (ABIN2666428) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details ProductDetails: References for anti-TNFRSF12A antibody (ABIN2666428) Images back to top
Concentration 1.0 mg/mL
Preservative Azide free
Storage 4 °C

ProductDetails: References for anti-TNFRSF12A antibody (ABIN2666428)

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling Images back to top
Background publications

Muñoz-García, Martín-Ventura, Martínez, Sánchez, Hernández, Ortega, Ortiz, Egido, Blanco-Colio: "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin." in: Stroke; a journal of cerebral circulation, Vol. 37, Issue 8, pp. 2044-53, 2006

Felli, Pedini, Zeuner, Petrucci, Testa, Conticello, Biffoni, Di Cataldo, Winkles, Peschle, De Maria: "Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 3, pp. 1464-72, 2005

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002

Feng, Guo, Factor, Thorgeirsson, Bell, Testa, Peifley, Winkles: "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas." in: The American journal of pathology, Vol. 156, Issue 4, pp. 1253-61, 2000

Meighan-Mantha, Hsu, Guo, Brown, Feng, Peifley, Alberts, Copeland, Gilbert, Jenkins, Richards, Winkles: "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration." in: The Journal of biological chemistry, Vol. 274, Issue 46, pp. 33166-76, 2000

Lynch, Wang, Lund, Chen, Leal, Wiley: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, 1999

Images

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Supplier Images
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody (ABIN2666428) anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) antibody