anti-Mouse (Murine) TNFRSF12A antibody for Functional Studies

Recommended TNFRSF12A Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
  • CD266
  • FN14
  • TWEAKR
  • AI255180
  • C87282
  • Fn14
  • HPIP
  • TWEAK-R
  • TweakR
  • tumor necrosis factor receptor superfamily, member 12A
  • tumor necrosis factor receptor superfamily, member 12a
  • TNFRSF12A
  • Tnfrsf12a
Reactivity
Human, Mouse (Murine)
93
58
30
3
3
2
2
2
2
1
1
1
Host
Mouse
51
41
8
3
Clonality
Monoclonal
Conjugate
This TNFRSF12A antibody is un-conjugated
11
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Western Blotting (WB)
53
48
20
17
16
13
13
12
3
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN2749025
$ 231.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2749122 Func IHC (f) FACS WB PE Mouse IgG2b Log in to see ITEM-4 3
1 ABIN2749054 Func IHC (f) FACS WB Mouse IgG2b Log in to see ITEM-4 3
1 ABIN3199690 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN3199692 FACS Func IHC (fro) WB PE Mouse IgG2b Log in to see ITEM-4
1 ABIN3199691 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN5540154 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN5540153 FACS Func IHC (fro) WB Mouse IgG2b Log in to see ITEM-4
1 ABIN3037011 Func FACS IHC WB Mouse IgG2b Log in to see
1 ABIN3037013 Func FACS IHC WB PE Mouse IgG2b Log in to see
1 ABIN3037012 Func FACS IHC WB Mouse IgG2b Log in to see
1 ABIN2142027 Func ELISA Mouse IgG2b kappa Log in to see ITEM-4

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antibodies
Reactivity Human, Mouse (Murine)
(93), (58), (30), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Mouse
(51), (41), (8), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF12A antibody is un-conjugated
(11), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Western Blotting (WB)
(53), (48), (20), (17), (16), (13), (13), (12), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-TNFRSF12A Antibody

Target Details TNFRSF12A Application Details Handling References for anti-TNFRSF12A antibody (ABIN2749025) Images
Specificity The mouse monoclonal antibody ITEM-4 recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Sterility 0.2 μm filtered
Endotoxin Level Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Immunogen human CD266-transfected P815 cells
Clone ITEM-4
Isotype IgG2b

Target Details TNFRSF12A

Product Details anti-TNFRSF12A Antibody Application Details Handling References for anti-TNFRSF12A antibody (ABIN2749025) Images back to top
Antigen
Alternative Name CD266 / TWEAK R (TNFRSF12A Antibody Abstract)
Background CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Pathways Apoptosis, Regulation of Cell Size

Application Details

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Handling References for anti-TNFRSF12A antibody (ABIN2749025) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details References for anti-TNFRSF12A antibody (ABIN2749025) Images back to top
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

References for anti-TNFRSF12A antibody (ABIN2749025)

Product Details anti-TNFRSF12A Antibody Target Details TNFRSF12A Application Details Handling Images back to top
Product cited in:

Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, 2012

Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant: "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1593-605, 2010

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002