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|Application / Reactivity||Mouse (Murine)|
|Blocking Reagent (BR)||2 Antibodies|
|Enzyme Immunoassay (EIA)||5 Antibodies|
|Flow Cytometry (FACS)||4 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Mass Cytometry (CyTOF)||2 Antibodies|
|Western Blotting (WB)||46 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Host||Armenian Hamster Alternatives|
|Conjugate||This TNFRSF25 antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|7 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF25 AntibodyTarget Details TNFRSF25 Application Details Handling References for anti-TNFRSF25 Antibody (ABIN2662708) Images
|Purification||The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details TNFRSF25Product Details anti-TNFRSF25 Antibody Application Details Handling References for anti-TNFRSF25 Antibody (ABIN2662708) Images back to top
|Alternative Name||DR3 (TNFRSF25 Antibody Abstract)|
|Background||DR3, also known as TNFRSF25, lymphocyte-associated receptor of death (LARD), WSL-1, TRAMP, TR3 and APO3, is a 55 kD glycoprotein belonging to the TNF receptor superfamily (TNFRSF). TNFSF25 is expressed at low level on CD4-positive, CD8-positive T cells and NKT cells. It has been shown to stimulate NF-κB activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domains containing adaptor proteins. Recently, it has been shown that TNFRSF25 is also expressed on Treg cells and regulates Treg proliferation.|
|Research Area||Signaling, Apoptosis/Necrosis, Death Receptors, Major Histocompatibility Complex (MHC)|
Application DetailsProduct Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Handling References for anti-TNFRSF25 Antibody (ABIN2662708) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Application Details References for anti-TNFRSF25 Antibody (ABIN2662708) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFRSF25 Antibody (ABIN2662708)Product Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Application Details Handling Images back to top
Longman, Diehl, Victorio et al.: "CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22." in: The Journal of experimental medicine, Vol. 211, Issue 8, pp. 1571-83, 2014 (PubMed).
Schreiber, Wolf, Bodero et al.: "T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 7, pp. 3311-8, 2012 (PubMed).
Wolf, Schreiber, Tryphonopoulos et al.: "Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival." in: Transplantation, Vol. 94, Issue 6, pp. 569-74, 2012 (PubMed).
Slebioda, Rowley, Ferdinand et al.: "Triggering of TNFRSF25 promotes CD8⁺ T-cell responses and anti-tumor immunity." in: European journal of immunology, Vol. 41, Issue 9, pp. 2606-11, 2011 (PubMed).
Taraban, Ferdinand, Al-Shamkhani: "Expression of TNFRSF25 on conventional T cells and Tregs." in: The Journal of clinical investigation, Vol. 121, Issue 2, pp. 463-4; author reply 465, 2011 (PubMed).
Schreiber, Wolf, Tsai et al.: "Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation." in: The Journal of clinical investigation, Vol. 120, Issue 10, pp. 3629-40, 2010 (PubMed).
Fang, Adkins, Deyev et al.: "Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation." in: The Journal of experimental medicine, Vol. 205, Issue 5, pp. 1037-48, 2008 (PubMed).
ImagesProduct Details anti-TNFRSF25 Antibody Target Details TNFRSF25 Application Details Handling References for anti-TNFRSF25 Antibody (ABIN2662708) back to top