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Browse our TREX1 (TREX1) ELISA Kits

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three Prime Repair Exonuclease 1 ELISA Kits (TREX1)
On are 0 three Prime Repair Exonuclease 1 (TREX1) ELISA Kits from different suppliers available. Additionally we are shipping TREX1 Antibodies (55) and TREX1 Proteins (7) and many more products for this protein. A total of 69 TREX1 products are currently listed.
1661, AGS1, AU041952, CRV, DRN3, HERNS, RGD1309596
list all ELISA KIts Gene Name GeneID UniProt
Human TREX1 TREX1 11277 Q9NSU2
Mouse TREX1 TREX1 22040 Q91XB0
Rat TREX1 TREX1 100049583  

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More ELISA Kits for TREX1 Interaction Partners

Human three Prime Repair Exonuclease 1 (TREX1) interaction partners

  1. This study reviewed that Neurologic Phenotypes Associated with Mutations in TREX1 in patients with Aicardi-Goutieres Syndrome.

  2. Aicardie-Goutieres syndrome is described in a patient with a homozygous p.Arg114His mutation in the TREX1 gene.

  3. CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated.

  4. Aicardi-Goutieres syndrome 1 is caused by mutations in the three prime repair exonuclease 1 gene (TREX1, MIM 606609).

  5. Functional analysis of retinal vasculopathy with cerebral leukodystrophy-associated TREX1 T270 frameshift-mutated fibroblasts showed a prevalent localization of the protein in the cytosol, rather than in the perinuclear region

  6. Here we briefly describe the human diseases so-far associated with mutations in TREX1, which include Aicardi-Goutieres syndrome, familial chilblain lupus, systemic lupus erythematosus and retinal vasculopathy with cerebral leukodystrophy

  7. Studies indicate that the biosensing strategy is based on the protection of DNA duplex from exonuclease (show EXO1 ELISA Kits) III (Exo III)-mediated digestion by specific binding of estrogen receptor (ER (show ESR1 ELISA Kits)) to its DNA response element.

  8. The authors observed that the minor allele of SNP rs3135941 in Trex1 is associated with faster HIV-1 disease progression.

  9. Unlike previously reported TREX1 mutations, which affect Exo I or Exo II domains, the mutation presented here alters the Exo III domain, suggesting a role of mutations within the catalytic Exo domains in the pathogenesis of familial chilblain lupus

  10. Data suggest that the 3'-5' DNA exonuclease (show EXO1 ELISA Kits) TREX1 may contribute to stabilization of poly(ADP-ribose) polymerase-1 (PARP1 (show PARP1 ELISA Kits)) levels in the DNA damage response and its activity.

Mouse (Murine) three Prime Repair Exonuclease 1 (TREX1) interaction partners

  1. Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 knockout (Trex1-/-) cells.

  2. Data show that cyclic GMP (show NT5C2 ELISA Kits)-AMP (show TMPRSS5 ELISA Kits) synthase (cGAS) is essential for all aspects of the autoimmune disease in 3' repair exonuclease (show EXO1 ELISA Kits) Trex1 knockout mice.

  3. Dysfunctional dsDNA degradation by TREX1 D18N induces disease in mice that recapitulates many characteristics of human lupus.

  4. DC activation induced by TLR3 (show TLR3 ELISA Kits), -4, -7, and -9 ligands also augments Trex1 expression through autocrine IFN-beta (show IFNB1 ELISA Kits) production and triggering of the IFN signaling pathway

  5. knocking out the DNA sensor cyclic GMP (show NT5C2 ELISA Kits)-AMP (show TMPRSS5 ELISA Kits) synthase completely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells.

  6. Spontaneous type I INF (show GIF ELISA Kits) dependent cutaneous pathology in TREX1 deficiency illustrates common pathogenetic pathway in chilblain lupus.

  7. Upon proinflammatory stimulation, Trex1(-/-) macrophages increase CD86 (show CD86 ELISA Kits), TNF-alpha (show TNF ELISA Kits) & IFN-alpha (show IFNA ELISA Kits) production, & Ag presentation to CD4 (show CD4 ELISA Kits)(+) T cells, but decrease apoptotic T cell clearance. Trex1 is a negative regulator of macrophage inflammatory activation.

  8. Oxidized DNA Is less susceptible to TREX1 degradation; the oxidized base 8-hydroxyguanosine, a marker of oxidative damage in DNA, potentiated cytosolic immune recognition by decreasing its susceptibility to 3' repair exonuclease 1 -mediated degradation

  9. regulates lysosomal biogenesis and interferon (show IFNA ELISA Kits)-independent activation of antiviral genes

  10. The structures of the mutant TREX1 proteins provide insight into the dysfunction relating to human disease.

TREX1 Antigen Profile

Antigen Summary

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TREX1

  • three prime repair exonuclease 1 (CpipJ_CPIJ012074) Elisa Kit
  • three prime repair exonuclease 1 (Tsp_03749) Elisa Kit
  • three prime repair exonuclease 1 (TREX1) Elisa Kit
  • three prime repair exonuclease 1 (Trex1) Elisa Kit
  • 1661 Elisa Kit
  • AGS1 Elisa Kit
  • AU041952 Elisa Kit
  • CRV Elisa Kit
  • DRN3 Elisa Kit
  • HERNS Elisa Kit
  • RGD1309596 Elisa Kit

Protein level used designations for TREX1

three prime repair exonuclease 1 , 3' repair exonuclease 1 , 3'-5' exonuclease TREX1 , DNase III , deoxyribonuclease III , three prime exonuclease 1 , trophoblast expressed 1

6045034 Culex quinquefasciatus
10910476 Trichinella spiralis
11277 Homo sapiens
22040 Mus musculus
100049583 Rattus norvegicus
282099 Bos taurus
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