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anti-Mouse (Murine) XIAP antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended XIAP Antibody (supplied by: Log in to see )

Antigen
X-Linked Inhibitor of Apoptosis (XIAP) Antibodies
  • 1110015C02Rik
  • Aipa
  • Api3
  • API3
  • api3
  • birc4
  • Birc4
  • BIRC4
  • hIAP-3
  • hIAP3
  • IAP-3
  • IAP3
  • ILP-1
  • ILP1
  • ilp1
  • MIHA
  • miha
  • mXIAP
  • riap3
  • xlp2
  • XLP2
  • xxiap
Epitope
AA 230-280
26
22
12
8
8
7
6
5
5
4
4
4
3
3
3
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
167
62
42
6
4
4
2
2
Host
Rabbit
149
23
1
Clonality
Polyclonal
Conjugate
This XIAP antibody is un-conjugated
6
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
144
68
57
42
27
22
10
10
10
9
3
2
1
1
1
Supplier
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Catalog No. ABIN674364
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008837508 ABIN920176 IF (cc) IF (p) Alexa Fluor 488 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN920179 IF (cc) IF (p) Alexa Fluor 647 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN920178 IF (cc) IF (p) Alexa Fluor 555 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN920180 IF (cc) IF (p) Alexa Fluor 350 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN674367 IF (cc) IF (p) Cy3 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN674369 IF (cc) IF (p) Cy5.5 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN674368 IF (cc) IF (p) Cy5 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN674370 IF (cc) IF (p) Cy7 Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN674371 IF (cc) IF (p) FITC Rabbit IgG AA 230-280 Log in to see Polyclonal
0.0008837508 ABIN2814997 IF (cc) IF (p) Alexa Fluor 594 Rabbit IgG AA 230-280 Log in to see Polyclonal

Top referenced anti-XIAP antibody for Immunofluorescence (Paraffin-embedded Sections)

Similar anti-XIAP Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 7 Antibodies 13 Antibodies
Immunofluorescence (IF) 4 Antibodies 10 Antibodies
Immunofluorescence (Cultured Cells) (IF (cc)) 11 Antibodies 11 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 18 Antibodies 29 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 14 Antibodies 21 Antibodies
Immunoprecipitation (IP) 10 Antibodies 12 Antibodies
Western Blotting (WB) 32 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Immunocytochemistry (ICC) 3 Antibodies

General

Antigen X-Linked Inhibitor of Apoptosis (XIAP) Antibodies
Epitope AA 230-280
(26), (22), (12), (8), (8), (7), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(167), (62), (42), (6), (4), (4), (2), (2)
Host Rabbit
(149), (23), (1)
Clonality
Polyclonal
Conjugate This XIAP antibody is un-conjugated
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(144), (68), (57), (42), (27), (22), (10), (10), (10), (9), (3), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-XIAP Antibody

Target Details XIAP Application Details Handling References for anti-XIAP Antibody (ABIN674364) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from mouse XIAP
Isotype IgG

Target Details XIAP

Product Details anti-XIAP Antibody Application Details Handling References for anti-XIAP Antibody (ABIN674364) Images back to top
Antigen
Alternative Name Xiap (XIAP Antibody Abstract)
Background

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Subcellular location: Cytoplasm, Nucleus


Synonyms: Aipa, Api3, IAP3, MIHA, Birc4, ILP-1, 11115C2Rik, E3 ubiquitin-protein ligase XIAP, Baculoviral IAP repeat-containing protein 4, IAP homolog A, Inhibitor of apoptosis protein 3, IAP-3, mIAP-3, mIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP, Xiap
Gene ID 11798
UniProt Q60989
Pathways Apoptosis, Caspase Cascade in Apoptosis

Application Details

Product Details anti-XIAP Antibody Target Details XIAP Handling References for anti-XIAP Antibody (ABIN674364) Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-XIAP Antibody Target Details XIAP Application Details References for anti-XIAP Antibody (ABIN674364) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-XIAP Antibody (ABIN674364)

Product Details anti-XIAP Antibody Target Details XIAP Application Details Handling Images back to top
Product cited in:

Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." in: Journal of bioenergetics and biomembranes, 2015

Chen, Xie, Zhao, Wang, Bai, Yin, Jiang, Xie, Jia, Huang et al.: "Ampelopsin induces apoptosis by regulating multiple c?Myc/S?phase kinase?associated protein 2/F?box and WD repeat?containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma ..." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 105-12, 2014

Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: "Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549." in: PLoS ONE, Vol. 8, Issue 11, pp. e79201, 2013

Images

Product Details anti-XIAP Antibody Target Details XIAP Application Details Handling References for anti-XIAP Antibody (ABIN674364) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 230-280) (ABIN674364) Formalin-fixed and paraffin embedded human endometrial tissue labeled with Anti-XIAP/...