X-linked inhibitor of apoptosis protein (XIAP) is an apoptotic suppressor. XIAP has E3 ubiquitin-protein ligase activity. XIAP mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. XIAP is an inhibitor of caspase-3, -7 and -9. XIAP mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2). XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV).
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4 with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.