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|Antigen||X-Linked Inhibitor of Apoptosis (XIAP) Antibodies|
|Epitope||AA 268-426 Alternatives|
|Reactivity||Frog, Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This XIAP antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-XIAP AntibodyTarget Details XIAP Application Details Handling ProductDetails: References for anti-XIAP antibody (ABIN968163) Images
|Cross-Reactivity||Rat (Rattus), Mouse (Murine), Frog|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human hILP aa. 268-426|
Target Details XIAPProduct Details anti-XIAP Antibody Application Details Handling ProductDetails: References for anti-XIAP antibody (ABIN968163) Images back to top
|Alternative Name||hILP (XIAP Antibody Abstract)|
Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms. Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival. Therefore, many viruses encode proteins that protect the cell from apoptosis. hILP (human IAP-like protein) is a human homologue of the viral IAP (Inhibitor of Apoptosis Protein). hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain. hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1beta converting enzyme) expression. This product is sold under license from Aegera Therapeutics, Inc. This antibody is routinely tested by western blot analysis.
|Molecular Weight||57 kDa|
|Pathways||Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis|
Application DetailsProduct Details anti-XIAP Antibody Target Details XIAP Handling ProductDetails: References for anti-XIAP antibody (ABIN968163) Images back to top
Related Products: ABIN968537, ABIN967389
|Restrictions||For Research Use only|
HandlingProduct Details anti-XIAP Antibody Target Details XIAP Application Details ProductDetails: References for anti-XIAP antibody (ABIN968163) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20° C.|
ProductDetails: References for anti-XIAP antibody (ABIN968163)Product Details anti-XIAP Antibody Target Details XIAP Application Details Handling Images back to top
|Product cited in:||
Deng, Lin, Wu: "TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO." in: Genes & development, Vol. 16, Issue 1, pp. 33-45, 2002
Martins, Iaccarino, Tenev, Gschmeissner, Totty, Lemoine, Savopoulos, Gray, Creasy, Dingwall, Downward: "The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 439-44, 2002
Fulda, Meyer, Debatin: "Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression." in: Cancer research, Vol. 60, Issue 14, pp. 3947-56, 2000
Tamm, Kornblau, Segall, Krajewski, Welsh, Kitada, Scudiero, Tudor, Qui, Monks, Andreeff, Reed: "Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 5, pp. 1796-803, 2000
Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: "A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2685-94, 1996
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