Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
our study revealed a novel microRNA signaling pathway involved in cholangiocarcinoma and suggests that manipulation of the miR (show MLXIP ELISA Kits)-410/XIAP pathway could have a therapeutic potential for cholangiocarcinoma
Blocking the MDM2 (show MDM2 ELISA Kits) protein-XIAP mRNA interaction reduces MDM2 (show MDM2 ELISA Kits) and XIAP levels and activates p53 (show TP53 ELISA Kits).
Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated non-small cell lung cancer to pro-apoptotic agents.
XIAP interacts with FAF1 (show FAF1 ELISA Kits) and blocks FAF1 (show FAF1 ELISA Kits)-induced cell death.
The study identifies an unanticipated role for the X-linked inhibitor of apoptosis (XIAP) protein as a regulator of Lys63-linked polyubiquitination of HIF1alpha (show HIF1A ELISA Kits).
The authors find that primary human aggressive B-cell lymphoma samples exhibit high USP9X (show USP9X ELISA Kits) expression that correlate with XIAP overexpression.
Findings reveal important new insights into how XIAP 3'UTR (show UTS2R ELISA Kits) works, suggesting that the non-coding XIAP 3'UTR (show UTS2R ELISA Kits) serves as a competitor for miRNA binding and subsequently inactivates miRNA functions, by which XIAP 3'UTR (show UTS2R ELISA Kits) frees the target mRNAs from being repressed.
XIAP is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1 (show CDK1 ELISA Kits)-cyclin-B1 (show CCNB1 ELISA Kits) at S40.
our findings suggest that X-linked inhibitor of apoptosis protein 3'-untranslated region serves as a competitive endogenous RNA for HMGA2 to activate hepatocellular carcinoma progression by arresting endogenous let-7a-5p.
In chronic myeloid leukemia (show BCL11A ELISA Kits) cells, EZH2 (show EZH2 ELISA Kits) modulates epigenetic changes at DNA methylated regions encoding miR (show MLXIP ELISA Kits)-219 and downregulates the level of miR (show MLXIP ELISA Kits)-219. Downregulation of miR (show MLXIP ELISA Kits)-219 results in upregulation of XIAP and supports the survival of leukemia cells.
Deletion of XIAP switches cell death away from necrosis to apoptosis.
These results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 (show CASP3 ELISA Kits) activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
XIAP antagonizes the switch from TNFalpha (show TNF ELISA Kits)-induced apoptosis to necroptosis in mouse neutrophils.
Results show that XIAP binds to the C terminus of Ptch1 (show PTCH1 ELISA Kits) and mediates the death-dependent function of Ptch1 (show PTCH1 ELISA Kits).
XIAP modulates ubiquitylation of RIP1 (show RALBP1 ELISA Kits) and suppresses RIP3 (show MPRIP ELISA Kits)-dependent cell death and inflammasome activation in response to TNF (show TNF ELISA Kits)-signaling in innate immune cells.
XIAP deficiency selectively impaired B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10 (show BCL10 ELISA Kits))-mediated innate responses to dectin-1 (show CLEC7A ELISA Kits) ligands but did not affect responses to various Toll (show TLR4 ELISA Kits)-like receptor agonists.
XIAP mRNA level was also reduced in the BRE (show BRE ELISA Kits)-depleted cells, but the level of reduction was less profound than that of the protein level. However, BRE (show BRE ELISA Kits) could not delay protein turnover of XIAP.
Identify xIAP and cIAP1 (show BIRC2 ELISA Kits) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
XIAP-/- DRG sensory neurons degenerate more rapidly and contain more active caspase-3 (show CASP3 ELISA Kits).
XIAP ubiquitylates RIPK2 (show RIPK2 ELISA Kits) and recruits the linear ubiquitin chain assembly complex to NOD2 (show NOD2 ELISA Kits)
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
E3 ubiquitin-protein ligase XIAP
, IAP-like protein
, X-linked IAP
, baculoviral IAP repeat-containing protein 4
, inhibitor of apoptosis protein 3
, Baculoviral IAP repeat-containing protein 4
, X-linked inhibitor of apoptosis protein
, baculoviral IAP repeat-containing 4
, baculoviral IAP-repeat containing protein 4
, IAP homolog A
, apoptosis inhibitor 3
, apoptosis inhibitor protein 3
, baculoviral IAP repeat containing 8