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|Antigen||tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, theta Polypeptide (YWHAQ) Antibodies|
|Reactivity||Chicken, Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Sheep (Ovine) Alternatives|
|Conjugate||This YWHAQ antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-YWHAQ AntibodyTarget Details YWHAQ Application Details Handling Images
|Specificity||Recognizes 14-3-3 tau/theta in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins involved in multiple cell signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preferences for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 tau/theta is primarily expressed in T-cells although it occurs at lower levels in the brain, heart, pancreas placenta and kidneys. It plays a role in cell cycle progression via interaction with p27(Kip1). Along with COPI, the theta isoform binds the GB1 RSR sequence involved in protein trafficking. The isoform forms a complex with Hsp60 and cellular prion protein which may be involved in prion diseases. Elevated levels of 14-3-3 tau/theta are observed in amyotrophic lateral sclerosis. 14-3-3 tau/theta also binds BCR/Abl, bacterial effector protein Tir, yes-associated protein and the FSH receptor. May not react with recombinant proteins that are not N-acetylated.|
Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 tau/theta.
Type of Immunogen: Synthetic peptide
Target Details YWHAQProduct Details anti-YWHAQ Antibody Application Details Handling Images back to top
|Alternative Name||YWHAQ / 14-3-3 Theta (YWHAQ Antibody Abstract)|
Name/Gene ID: YWHAQ
Synonyms: YWHAQ, 14-3-3 protein T-cell, 14-3-3 protein theta, 14-3-3 protein tau, 14-3-3, 14-3-3 Tau, 1C5, Protein HS1, HS1, Protein tau
|Pathways||Apoptosis, Myometrial Relaxation and Contraction|
Application DetailsProduct Details anti-YWHAQ Antibody Target Details YWHAQ Handling Images back to top
Approved: ELISA, IHC-P (1:60), WB (1:3000)
Usage: Western Blot: LS-C42376 detects a band of approximately 30kD in HEK293 cell lysates. Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
|Restrictions||For Research Use only|
HandlingProduct Details anti-YWHAQ Antibody Target Details YWHAQ Application Details Images back to top
|Buffer||Serum, 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeat freeze-thaw cycles.|
|Storage||4 °C,-20 °C|
Long term: -20°C
Short term: +4°C. Avoid repeat freeze-thaw cycles.