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|Antigen||tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, theta Polypeptide (YWHAQ) Antibodies|
|Reactivity||Cow (Bovine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This YWHAQ antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-YWHAQ AntibodyTarget Details YWHAQ Application Details Handling ProductDetails: References for anti-YWHAQ antibody (ABIN264385) Images
|Specificity||This antibody reacts specifically with the theta/tau isoform.|
|Characteristics||Synonyms: 14-3-3 protein tau, 14-3-3 protein T-cell, YWHAQ, Protein HS1|
Target Details YWHAQProduct Details anti-YWHAQ Antibody Application Details Handling ProductDetails: References for anti-YWHAQ antibody (ABIN264385) Images back to top
|Alternative Name||14-3-3 Protein theta (YWHAQ Antibody Abstract)|
|Background||At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.Synonyms: 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1, YWHAQ|
|Molecular Weight||31 kDa|
|Research Area||Transcription Factors|
|Pathways||Apoptosis, Myometrial Relaxation and Contraction|
Application DetailsProduct Details anti-YWHAQ Antibody Target Details YWHAQ Handling ProductDetails: References for anti-YWHAQ antibody (ABIN264385) Images back to top
Suitable for use in Western Blot (1/5000). Positive controls: 3T3, PC12, Jurkat.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-YWHAQ Antibody Target Details YWHAQ Application Details ProductDetails: References for anti-YWHAQ antibody (ABIN264385) Images back to top
|Buffer||20 mM Sodium Phosphate, pH 7.5, 150 mM Sodium Chloride, 50 % Glycerol.|
Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
|Expiry Date||12 months|
ProductDetails: References for anti-YWHAQ antibody (ABIN264385)Product Details anti-YWHAQ Antibody Target Details YWHAQ Application Details Handling Images back to top
|Product cited in:||
Patel, Cummings, Batchelor, Hill, Dubois, Mellits, Frankel, Connerton: "Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization." in: Cellular microbiology, Vol. 8, Issue 1, pp. 55-71, 2005
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