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this study reveals that 14-3-3zeta (show YWHAZ ELISA Kits) plays a critical role in Wnt5a (show WNT5A ELISA Kits)/ROR1 (show ROR1 ELISA Kits) signaling, leading to enhanced CLL migration and proliferation.
AKT (show AKT1 ELISA Kits) and 14-3-3 proteins down-regulate the activity of several BCR (show BCR ELISA Kits)-associated components, including BTK (show BTK ELISA Kits), BLNK (show BLNK ELISA Kits) and SYK (show SYK ELISA Kits) and also inhibit SYK's interaction with Importin 7 (show IPO7 ELISA Kits)
Our results indicate that TRIM25 (show TRIM25 ELISA Kits) is associated with cisplatin resistance and 14-3-3sigma-MDM2 (show MDM2 ELISA Kits)-p53 (show TP53 ELISA Kits) signaling pathway is involved in this process, suggesting targeting TRIM25 (show TRIM25 ELISA Kits) may be a potential strategy for the reversal of cisplatin resistance.
Up-regulation of 14-3-3zeta (show YWHAZ ELISA Kits) in response to pVHL (show VHL ELISA Kits) is important for the recruitment of PI3K (show PIK3CA ELISA Kits) to the cell membrane and for stabilization of soluble beta-catenin (show CTNNB1 ELISA Kits).
The 14-3-3 family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon (show YWHAE ELISA Kits), theta and zeta isoforms could be useful indicators of disease severity.
High urine 14-3-3 expression is associated with Advanced Stage in Patients with Clear Cell Renal Cell Carcinoma.
Levels of 14-3-3 protein (show YWHAE ELISA Kits) predict poorer radiographic outcomes in inflammatory polyarthritis patients.
Study shows that 14-3-3 zeta (show YWHAZ ELISA Kits)/delta is important in the extracellular vesicles mediated induction of colon malignant phenotype, suggesting its role as a potential target for therapeutic interventions.
the effects of cell viability, migration and invasion were mediated in 14-3-3zeta (show YWHAZ ELISA Kits)-dependent manner while that of cell apoptosis was mediated in 14-3-3zeta (show YWHAZ ELISA Kits)-independent manner.
14-3-3zeta (show YWHAZ ELISA Kits) reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen (show PCNA ELISA Kits)
analysis of phosphorylation-dependent interactions of AQP2 (show AQP2 ELISA Kits) with 14-3-3theta; and -zeta
Data show that IkappaB kinase (show CHUK ELISA Kits) (IKK (show CHUK ELISA Kits)) phosphorylation of the TPL-2 (show MAP3K8 ELISA Kits) kinase (TPL-2 (show MAP3K8 ELISA Kits)) induces 14-3-3 association with TPL-2 (show MAP3K8 ELISA Kits), stimulating its MEK (show MDK ELISA Kits) kinase activity, which is essential for TPL-2 (show MAP3K8 ELISA Kits) activation of ERK-1 (show MAPK3 ELISA Kits)/2.
There is a scaffolding role for 14-3-3theta in assisting the delivery of Cx43 (show GJA1 ELISA Kits) and integrin alpha5 to the plasma membrane for the formation of mechanosensitive hemichannels in osteocytes.
14-3-3 negatively regulates the RGC downstream of the PI3-kinase (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway
14-3-3 theta is a new and important regulatory protein (show TGFB1 ELISA Kits) in the TLR-2 (show TLR2 ELISA Kits) and TLR-4 (show TLR4 ELISA Kits) signaling suppressing the MyD88 (show MYD88 ELISA Kits)-dependent pathway
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
14-3-3 protein tau
, 14-3-3 tau
, 14-3-3 theta
, 14-3-3 protein theta
, 14-3-3 protein T-cell
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide
, cerebellar 14-3-3 theta protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 2