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this study reveals that 14-3-3zeta (show YWHAZ Proteins) plays a critical role in Wnt5a (show WNT5A Proteins)/ROR1 (show ROR1 Proteins) signaling, leading to enhanced CLL migration and proliferation.
AKT (show AKT1 Proteins) and 14-3-3 proteins down-regulate the activity of several BCR (show BCR Proteins)-associated components, including BTK (show BTK Proteins), BLNK (show BLNK Proteins) and SYK (show SYK Proteins) and also inhibit SYK's interaction with Importin 7 (show IPO7 Proteins)
Our results indicate that TRIM25 (show TRIM25 Proteins) is associated with cisplatin resistance and 14-3-3sigma-MDM2 (show MDM2 Proteins)-p53 (show TP53 Proteins) signaling pathway is involved in this process, suggesting targeting TRIM25 (show TRIM25 Proteins) may be a potential strategy for the reversal of cisplatin resistance.
Up-regulation of 14-3-3zeta (show YWHAZ Proteins) in response to pVHL (show VHL Proteins) is important for the recruitment of PI3K (show PIK3CA Proteins) to the cell membrane and for stabilization of soluble beta-catenin (show CTNNB1 Proteins).
The 14-3-3 family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon (show YWHAE Proteins), theta and zeta isoforms could be useful indicators of disease severity.
High urine 14-3-3 expression is associated with Advanced Stage in Patients with Clear Cell Renal Cell Carcinoma (show MOK Proteins).
Levels of 14-3-3 protein (show YWHAE Proteins) predict poorer radiographic outcomes in inflammatory polyarthritis patients.
Study shows that 14-3-3 zeta (show YWHAZ Proteins)/delta is important in the extracellular vesicles mediated induction of colon malignant phenotype, suggesting its role as a potential target for therapeutic interventions.
the effects of cell viability, migration and invasion were mediated in 14-3-3zeta (show YWHAZ Proteins)-dependent manner while that of cell apoptosis was mediated in 14-3-3zeta (show YWHAZ Proteins)-independent manner.
14-3-3zeta (show YWHAZ Proteins) reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen (show PCNA Proteins)
analysis of phosphorylation-dependent interactions of AQP2 (show AQP2 Proteins) with 14-3-3theta; and -zeta
Data show that IkappaB kinase (show CHUK Proteins) (IKK (show CHUK Proteins)) phosphorylation of the TPL-2 (show MAP3K8 Proteins) kinase (TPL-2 (show MAP3K8 Proteins)) induces 14-3-3 association with TPL-2 (show MAP3K8 Proteins), stimulating its MEK (show MDK Proteins) kinase activity, which is essential for TPL-2 (show MAP3K8 Proteins) activation of ERK-1 (show MAPK3 Proteins)/2.
There is a scaffolding role for 14-3-3theta in assisting the delivery of Cx43 (show GJA1 Proteins) and integrin alpha5 to the plasma membrane for the formation of mechanosensitive hemichannels in osteocytes.
14-3-3 negatively regulates the RGC downstream of the PI3-kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway
14-3-3 theta is a new and important regulatory protein (show TGFB1 Proteins) in the TLR-2 and TLR-4 (show TLR4 Proteins) signaling suppressing the MyD88 (show MYD88 Proteins)-dependent pathway
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
14-3-3 protein tau
, 14-3-3 tau
, 14-3-3 theta
, 14-3-3 protein theta
, 14-3-3 protein T-cell
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide
, cerebellar 14-3-3 theta protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 2