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Human Polyclonal GABARAPL2 Primary Antibody for IHC, IHC (p) - ABIN4313669
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
rs12599322 in ATG8 was significantly associated with higher DNA damage levels in Chinese population.
describe a protocol for the reconstituted conjugation systems for mammalian Atg8 homologs in vitro using purified recombinant Atg proteins and liposomes.
Using X-ray crystallography and NMR spectroscopy, the structural transition centered on the C-terminus of GATE-16 protein was identified.
Results showed that the mRNA and protein levels of GABARAPL1 (show GABARAPL1 Antibodies) and GATE-16 were decreased in the cerebellum of multiple system atrophy relative to controls
Lipidation of the LC3 (show MAP1LC3A Antibodies)/GABARAP (show GABARAP Antibodies) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 (show ATG3 Antibodies).
these results suggest that TRPML3 (show Mcoln3 Antibodies) plays a role in autophagosome maturation through the interaction with GATE16, by providing Ca(2 (show CA2 Antibodies)+) in the fusion process.
low GABARAPL2/GATE-16 expression is associated with an immature myeloid leukemic phenotype and these proteins are necessary for neutrophil differentiation of APL (show FASL Antibodies) cells
TP53INP1 (show TP53INP1 Antibodies), a tumor suppressor, interacts with LC3 (show MAP1LC3A Antibodies) and ATG8-family proteins through the LC3 (show MAP1LC3A Antibodies)-interacting region (LIR (show CD300C Antibodies)) and promotes autophagy-dependent cell death.
ATG8 proteins act as scaffolds for assembly of the ULK complex at the phagophore
Legionella pneumophila could interfere with autophagy by using the bacterial effector protein RavZ to directly uncouple Atg8 proteins attached to phosphatidylethanolamine on autophagosome membranes. [RavZ]
Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced (show SAMHD1 Antibodies) clearance of vacuolar pathogens such as Toxoplasma. Gate-16 specifically associated with the small GTPase (show RACGAP1 Antibodies) ADP-ribosylation factor 1 (Arf1 (show ARF1 Antibodies)) to mediate uniform distribution of interferon (show IFNA Antibodies)-inducible GTPases. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of IFN-inducible GTPases.
Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).
GABA(A) receptor-associated protein-like 2
, gamma-aminobutyric acid receptor-associated protein-like 2
, ganglioside expression factor 2
, golgi-associated ATPase enhancer of 16 kDa
, MAP1 light chain 3 related protein
, MAP1 light chain 3-related protein
, general protein transport factor p16
, GABA(A) receptor-associated protein like 2
, gamma-aminobutyric acid (GABA-A) receptor-associated protein-like 2