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Mechanism of cargo-directed Atg8 conjugation during selective autophagy has been described.
Cardiolipin interaction with various Atg8 human orthologs, namely LC3B (show MAP1LC3B Proteins), GABARAPL2 and GABARAP (show GABARAP Proteins), was investigated.
rs12599322 in ATG8 was significantly associated with higher DNA damage levels in Chinese population.
describe a protocol for the reconstituted conjugation systems for mammalian Atg8 homologs in vitro using purified recombinant Atg proteins and liposomes.
Using X-ray crystallography and NMR spectroscopy, the structural transition centered on the C-terminus of GATE-16 protein was identified.
Results showed that the mRNA and protein levels of GABARAPL1 (show GABARAPL1 Proteins) and GATE-16 were decreased in the cerebellum of multiple system atrophy relative to controls
Lipidation of the LC3 (show MAP1LC3A Proteins)/GABARAP (show GABARAP Proteins) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 (show ATG3 Proteins).
these results suggest that TRPML3 plays a role in autophagosome maturation through the interaction with GATE16, by providing Ca(2 (show CA2 Proteins)+) in the fusion process.
low GABARAPL2/GATE-16 expression is associated with an immature myeloid leukemic phenotype and these proteins are necessary for neutrophil differentiation of APL (show FASL Proteins) cells
TP53INP1, a tumor suppressor, interacts with LC3 (show MAP1LC3A Proteins) and ATG8-family proteins through the LC3 (show MAP1LC3A Proteins)-interacting region (LIR (show CD300C Proteins)) and promotes autophagy-dependent cell death.
Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced (show SAMHD1 Proteins) clearance of vacuolar pathogens such as Toxoplasma. Gate-16 specifically associated with the small GTPase (show RACGAP1 Proteins) ADP-ribosylation factor 1 (Arf1 (show ARF1 Proteins)) to mediate uniform distribution of interferon (show IFNA Proteins)-inducible GTPases. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of IFN-inducible GTPases.
Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).
GABA(A) receptor-associated protein-like 2
, gamma-aminobutyric acid receptor-associated protein-like 2
, ganglioside expression factor 2
, golgi-associated ATPase enhancer of 16 kDa
, MAP1 light chain 3 related protein
, MAP1 light chain 3-related protein
, general protein transport factor p16
, GABA(A) receptor-associated protein like 2
, gamma-aminobutyric acid (GABA-A) receptor-associated protein-like 2