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Human MAP1LC3B Protein expressed in Wheat germ - ABIN1310156
Martinet, Schrijvers, Timmermans, Bult, De Meyer: Immunohistochemical analysis of macroautophagy: recommendations and limitations. in Autophagy 2013
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Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR (show FRAP1 Proteins), Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
Determined is the three-dimensional crystal structures of LC3B in complex with three different LIR (show CD300C Proteins) motifs of RavZ from Legionella pneumophila, an intracellular pathogen that can manipulate the host autophagy system.
We found that 25-epi (show TFPI Proteins) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (show HSPA5 Proteins) expression, increased expression of the ER stress marker CHOP (show DDIT3 Proteins), loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B.
Double IF showed the co-localization of AQP5 (show AQP5 Proteins) and LC3B on BafA1-treated heated cells. In conclusion, we demonstrated that heat shock decreased AQP5 (show AQP5 Proteins) on cellular membranes and in the cytoplasm by activating autophagic degradation, and heat shock and AQP5 (show AQP5 Proteins) knockdown exerted similar anticancer effects, suggesting that heat shock exerts anticancer effects via the autophagic degradation of AQP5 (show AQP5 Proteins).
structural and biochemical results reveal a working model for the specific recognition of FUNDC1 (show FUNDC1 Proteins) by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.
Low expression of MAP1LC3B is associated with lymph node metastasis in gastric cancer.
Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation
BAG3 (show BAG3 Proteins) maintains the basal amount of LC3B protein by controlling the translation of its mRNA in HeLa and HEK293 cells.
Among the 101 patients, the frequency of high expression of beclin-1 (show BECN1 Proteins) was 31.7% (32/101) and that of LC3b was 46.5% (47/101). A pathologic complete response was inversely associated with LC3b expression (P = 0.003) and alterations in the expression of autophagy-related proteins
Collectively, our findings indicate that MIR494 reduces cell survival in 769-P renal cancer cells which is accompanied by increased lipid droplet formation (which occurs in a LC3B-dependent manner) and mitochondrial changes.
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2 (show TRDMT1 Proteins)) siRNA restored the expression of Atg5 (show ATG5 Proteins) and LC3 (show MAP1LC3A Proteins) in vivo and in vitro.
MREG (show MREG Proteins)-dependent processing links both autophagic and phagocytic processes in LC3 (show MAP1LC3A Proteins)-associated phagocytosis. MREG (show MREG Proteins) participates in coordinating the association of phagosomes with LC3 (show MAP1LC3A Proteins) for content degradation with the MREG (show MREG Proteins) loss leading to phagosome accumulation.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Deficiency of autophagy protein Map1 (show MOAP1 Proteins)-LC3b mediates IL-17 (show IL17A Proteins)-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1 (show IL1A Proteins).
This study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
Data indicate that the recombinant plasmid encoding pCMV-LC3 (show MAP1LC3A Proteins)-LpqH could be a practical strategy for the development of improved vaccines against Mycobacterium tuberculosis.
Lipidation of the LC3 (show MAP1LC3A Proteins)/GABARAP (show GABARAP Proteins) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 (show ATG3 Proteins).
p62 (show GTF2H1 Proteins)/LC3b complex regulates lung alveolar epithelial cell homeostasis and cytoprotection after hyperoxia.
Lc3 (show MAP1LC3A Proteins) over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice.
LC3B plays a regulatory role in hyperoxia-induced epithelial apoptosis
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
microtubule-associated proteins 1A/1B light chain 3B
, microtubule-associated protein 1 light chain 3 beta
, MAP1 light chain 3-like protein 2
, MAP1A/MAP1B LC3 B
, MAP1A/MAP1B light chain 3 B
, autophagy-related ubiquitin-like modifier LC3 B
, autophagy-related protein LC3 B
, MAP1A/1B light chain 3 B
, microtubule-associated proteins 1A/1B light chain 3