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ZIP2 Gln/Arg/Leu polymorphism involve in proinflammatory mediation and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype
results of this study suggest that ZIP2, a zinc transporter expressed specifically in the epidermis, and zinc taken up by ZIP2 are necessary for the differentiation of keratinocytes
Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls.
Increased expression of Zip2 gene is closely associated with immunity of pulmonary tuberculosis patients, suggesting that the Zip2 gene may play a key role in initial infection control.
Expression of two Zn2+ influx transporters, ZIP2 and ZIP4, is reduced as a function of retinal pigment epithelium age.
ZiP2 and Zip3 (show SLC39A3 Antibodies) are down regulated in malignant cells
regulation of ZIP2 protein in human breast cancer xenografts
Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.
ZIP1 (show SLC39A1 Antibodies), ZIP2 and ZIP3 (show SLC39A3 Antibodies) may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc
These studies suggest that active expression of the Zip2 gene in these few specific cell types, aforementioned, plays a particularly important role during zinc deficiency.
Slc39a2 apparently plays a critical role in zinc homeostasis when zinc is replete, but they play important, noncompensatory roles when this metal is deficient
This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described.
solute carrier family 39 (zinc transporter), member 2
, zinc transporter ZIP2
, Zrt- and Irt-like protein 2
, solute carrier family 39 member 2
, zinc uptake transporter 2