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These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.
Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
High plasma levels of TSP-1 are associated with increased pulmonary arterial pressure, increased pulmonary vascular resistance and decreased survival pulmonary hypertension.
Our data suggest that the molecular network including TSP-1, TGF-beta1 (show TGFB1 Proteins), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
Genetic variants of THBS1 were significantly more frequent in patients affected by idiopathic/genetic generalized epilepsies than in non-epileptic controls.
In pulmonary hypertension TSP1-CD47 (show CD47 Proteins) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
High THBS1 expression is associated with primary effusion lymphoma.
Results show that the presence of OPN (show SPP1 Proteins) and TSP-1 in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.
KLK4 (show KLK4 Proteins) further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix.
Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)
cultured astrocytes isolated from an Fmr1 (show FMR1 Proteins) knockout (Fmr1 (show FMR1 Proteins) KO) mouse model of Fragile X (show FMR1 Proteins) syndrome displayed a significant decrease in TSP-1 (show GZMA Proteins) protein expression compared to the wildtype (WT) astrocytes.
In pulmonary hypertension TSP1 (show GZMA Proteins)-CD47 (show CD47 Proteins) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
HIF-1alpha (show HIF1A Proteins) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (show MLXIP Proteins)-21 via inhibiting a novel target gene TSP-1 (show GZMA Proteins). Both of them may contribute to the protective effect of HIF-1alpha (show HIF1A Proteins) on renal I/R injury.
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show GZMA Proteins)/CD47 (show CD47 Proteins) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
TSP-1 (show GZMA Proteins) deficiency promotes maladaptive remodelling of the ECM (show MMRN1 Proteins) leading to accelerated abdominal aortic aneurysms progression.
TSP-1 (show GZMA Proteins) suppressed insulin (show INS Proteins) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (show MAPK8 Proteins), p38 (show CRK Proteins), and IKK (show CHUK Proteins).
Three transcription factors were overexpressed and eleven underexpressed in TSP1 (show GZMA Proteins)(-/-) compared to WT LGs (show LGSN Proteins).
Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
demonstrate that HIF-2alpha (show EPAS1 Proteins) is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Proteins), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Proteins)).
Thrombospondin has a role in inducing RhoA (show RHOA Proteins) inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Proteins)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Proteins) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Proteins)).
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Proteins) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Proteins) expression.
ELL (show ELL Proteins) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, thrombospondin 1