Browse our Thrombospondin 1 Proteins (THBS1)

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Thrombospondin 1 Proteins (THBS1)
On are 50 Thrombospondin 1 (THBS1) Proteins from 13 different suppliers available. Additionally we are shipping Thrombospondin 1 Antibodies (205) and Thrombospondin 1 Kits (61) and many more products for this protein. A total of 323 Thrombospondin 1 products are currently listed.
4833423O18Rik, CRISP-2, CT36, GAPDL5, si:dkey-11e23.1, tbsp1, thbs, thbs-1, THBS1, thrombospondin-1, Tmtsp, TPX1, tsp, Tsp-1, Tsp1, UNQ3010, wu:fc48c03
list all proteins Gene Name GeneID UniProt
THBS1 55901 Q9NS62
THBS1 364630  
THBS1 21825  

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Thrombospondin 1 Proteins (THBS1) by Origin

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More Proteins for Thrombospondin 1 Interaction Partners

Zebrafish Thrombospondin 1 (THBS1) interaction partners

  1. ELL (show ELL Proteins) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation

Human Thrombospondin 1 (THBS1) interaction partners

  1. Results show that the presence of OPN (show SPP1 Proteins) and TSP-1 in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.

  2. KLK4 (show KLK4 Proteins) further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix.

  3. Data suggest pituitary cells secrete factor (TSP1) that binds to and inhibits action of BMP2 and BMP4; von Willebrand type C domain of TSP1 is likely responsible for this BMP2/4-binding activity. These studies were initially conducted using cultured cells from ovine pituitary gland and mouse cell line; interactions were confirmed using recombinant human proteins. (TSP1 = thrombospondin-1; BMP = bone morphogenetic protein)

  4. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1/CD47 (show CD47 Proteins) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

  5. The levels of CD36 (show CD36 Proteins), STAT3 (show STAT3 Proteins) and TGFbetaR2 mRNA were significantly higher in the TSP1-high group.

  6. Study discovered novel and independent associations of prediabetes and related traits with MASP1 (show MASP1 Proteins), and some evidence for associations with THBS1, GPLD1 (show GPLD1 Proteins) and ApoA-IV (show APOA4 Proteins), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.

  7. TSP-1 deficiency promotes maladaptive remodelling of the ECM (show MMRN1 Proteins) leading to accelerated abdominal aortic aneurysms progression.

  8. Low THBS1 expression is associated with lung cancer.

  9. FGF7 (show FGF7 Proteins) stimulation of cell invasion and migration was partially suppressed by the FGFR2 (show FGFR2 Proteins) knockdown. In addition, FGF7 (show FGF7 Proteins)/FGFR2 (show FGFR2 Proteins) upregulated THBS1, and cell invasion and migration were decreased by knockdown of THBS1

  10. Introduces a computational model that describes the mechanistic interactions between intracellular biomolecules and cooperation between signaling pathways that together make up the complex network of TSP-1 regulation both at the transcriptional and post-transcriptional level.

Cow (Bovine) Thrombospondin 1 (THBS1) interaction partners

  1. Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Proteins) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Proteins), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Proteins)).

  2. Thrombospondin has a role in inducing RhoA (show RHOA Proteins) inactivation through FAK (show PTK2 Proteins)-dependent signaling to stimulate focal adhesion disassembly

  3. Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.

  4. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Proteins)-like growth factor

  5. The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications

  6. The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Proteins) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Proteins)).

Mouse (Murine) Thrombospondin 1 (THBS1) interaction partners

  1. HIF-1alpha (show HIF1A Proteins) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (show MLXIP Proteins)-21 via inhibiting a novel target gene TSP-1 (show GZMA Proteins). Both of them may contribute to the protective effect of HIF-1alpha (show HIF1A Proteins) on renal I/R injury.

  2. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show GZMA Proteins)/CD47 (show CD47 Proteins) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

  3. TSP-1 (show GZMA Proteins) deficiency promotes maladaptive remodelling of the ECM (show MMRN1 Proteins) leading to accelerated abdominal aortic aneurysms progression.

  4. TSP-1 (show GZMA Proteins) suppressed insulin (show INS Proteins) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (show MAPK8 Proteins), p38 (show CRK Proteins), and IKK (show CHUK Proteins).

  5. Three transcription factors were overexpressed and eleven underexpressed in TSP1 (show GZMA Proteins)(-/-) compared to WT LGs (show LGSN Proteins).

  6. Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.

  7. demonstrate that HIF-2alpha (show EPAS1 Proteins) is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction

  8. Thrombospondin-1 was differentially expressed according to tumor grade, but not affected by p53 (show TP53 Proteins) expression or mutational status

  9. Data suggest neutrophil protease- Tsp-1 (thrombospondin-1) axis as a potential antimetastatic therapeutic target.

  10. These results contribute new insights on the controversial role of TSP-1 (show GZMA Proteins) in cancer.

Pig (Porcine) Thrombospondin 1 (THBS1) interaction partners

  1. These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Proteins) and the mechanisms by which hyperglycemia regulates TSP-1 protein.

  2. Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Proteins) expression.

Thrombospondin 1 (THBS1) Protein Profile

Protein Summary

May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.

Alternative names and synonyms associated with Thrombospondin 1 (THBS1)

  • thrombospondin, type I, domain containing 1 (THSD1)
  • thrombospondin 1 (THBS1)
  • cysteine-rich secretory protein 2 (CRISP2)
  • thrombospondin, type I, domain containing 1 (Thsd1)
  • thrombospondin 1 (Thbs1)
  • thrombospondin 1 (thbs1)
  • thrombospondin 1 (LOC100230636)
  • thrombospondin, type I, domain 1 (Thsd1)
  • 4833423O18Rik protein
  • CRISP-2 protein
  • CT36 protein
  • GAPDL5 protein
  • si:dkey-11e23.1 protein
  • tbsp1 protein
  • thbs protein
  • thbs-1 protein
  • THBS1 protein
  • thrombospondin-1 protein
  • Tmtsp protein
  • TPX1 protein
  • tsp protein
  • Tsp-1 protein
  • Tsp1 protein
  • UNQ3010 protein
  • wu:fc48c03 protein

Protein level used designations for Thrombospondin 1 Proteins (THBS1)

4833423O18Rik , thrombospondin type-1 domain-containing protein 1 , thrombospondin, type I, domain 1 , transmembrane molecule with thrombospondin module , thrombospondin-1 , thrombospondin-1p180 , cancer/testis antigen 36 , glyceraldehyde-3-phosphate dehydrogenase-like 5 , testis specific protein 1 (probe H4-1 p3-1) , testis-specific protein TPX-1 , thrombospondin 1 , thrombospondin-1-like

55901 Homo sapiens
7057 Homo sapiens
7180 Homo sapiens
364630 Rattus norvegicus
21825 Mus musculus
281530 Bos taurus
373987 Gallus gallus
379508 Xenopus laevis
445442 Rattus norvegicus
453319 Pan troglodytes
487486 Canis lupus familiaris
492313 Sus scrofa
561901 Danio rerio
705413 Macaca mulatta
100170153 Xenopus (Silurana) tropicalis
100230636 Taeniopygia guttata
100294615 Ovis aries
100350430 Oryctolagus cuniculus
100390178 Callithrix jacchus
100453386 Pongo abelii
100465724 Ailuropoda melanoleuca
56229 Mus musculus
100057478 Equus caballus
100542373 Meleagris gallopavo
100603886 Nomascus leucogenys
101106433 Ovis aries
100727882 Cavia porcellus
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