Browse our Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteins (PTGS2)

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Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteins (PTGS2)
On www.antibodies-online.com are 10 Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Proteins from 6 different suppliers available. Additionally we are shipping Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Antibodies (232) and Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Kits (69) and many more products for this protein. A total of 322 Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) products are currently listed.
Synonyms:
CEF147, COII, Cox-2, Cox2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PGHS2, PHS-2, PHSII, PTGS2, TIS10
list all proteins Gene Name GeneID UniProt
PTGS2 19225 Q05769
PTGS2 29527 P35355
PTGS2 5743 P35354

Show all synonyms

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteins (PTGS2) by Origin

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More Proteins for Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Interaction Partners

Horse (Equine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. This study showed that COX-1 (show PTGS1 Proteins) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Proteins)-1 is more prominently expressed.

  2. Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (show OXTR Proteins), and cyclooxygenase 2 in fetal membranes and endometrium.

  3. COX-1 (show PTGS1 Proteins) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.

  4. The role for p38 (show MAPK14 Proteins) mitogen-activated kinase (MAPK (show MAPK1 Proteins)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (show CPOX Proteins)) gene expression in lipopolysaccharide (LPS (show IRF6 Proteins))-activated equine leukocytes in horses is reported.

  5. In this study, both COX-1 (show PTGS1 Proteins) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.

  6. Immunoreactivity for COX-1 (show PTGS1 Proteins) and COX-2 is high in equine corneal SCC (show CYP11A1 Proteins), possibly indicating that COX (show CPOX Proteins) plays a role in oncogenesis or progression of this tumor type at this site.

  7. It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.

  8. data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy

Cow (Bovine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.

  2. results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (show NR1D1 Proteins)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids

  3. This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (show LTF Proteins), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.

  4. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2, and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  5. Purinergic P2Y1 receptor (show P2RY1 Proteins) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts

  6. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.

  7. This study is the first to report the involvement of PGE2 in oocyte MAPK (show MAPK1 Proteins) activation during the maturation process.

  8. Inhibitors of c-Src (show SRC Proteins) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (show PGF Proteins)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.

  9. COX-2 pathway is responsible for the endometrial production of PGE (show LIPF Proteins)(2) in the bovine endometrium during the estrous cycle

  10. the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (show CSF2 Proteins) during the peri (show PLIN1 Proteins)-attachment period in the cow.

Mouse (Murine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. Salt supplementation during the COX-2-dependent time frame of nephrogenesis partly reverses renal morphological defects in COX-2(-/-) mice and improves kidney function.

  2. Data suggest that induction of Ptgs2 expression in preimplantation uterus may be earliest positive embryo/blastocyst signal for implantation and pregnancy recognition in mice.

  3. the bone regeneration capacity of Cox (show CPOX Proteins)-2KO MDSCs was impaired because of a reduction in cell proliferation and survival capacities, reduction in osteogenic differentiation and a decrease in the ability of the cells to recruit host cells to the injury site.

  4. these studies have demonstrated an important but unexpected role for macrophage COX-2/prostaglandin E2/PGE2 receptor subtype 4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 expression in intrinsic renal cells.

  5. Data (including data from studies using knockout/mutant mice) suggest that Mir200c (microRNA 200c) is involved in endothelial function/dysfunction via regulation of Cox2 (cyclooxygenase-2) expression; overexpression of Mir200c impairs endothelium-dependent vascular relaxation (EDVR) in non-diabetic mouse aorta, whereas suppression of Mir200c by anti-Mir200c enhances EDVR in diabetic mouse aorta.

  6. data indicate that excessive adipocyte lipolysis activates the JNK (show MAPK8 Proteins)/NFkappaB pathway leading to the up-regulation of COX-2 expression and recruitment of inflammatory macrophages.

  7. this study shows that c-Jun (show JUN Proteins) regulates the activation state of macrophages and promotes arthritis via differentially regulating cyclooxygenase-2 and arginase-1 (show ARG1 Proteins) levels

  8. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.

  9. Data suggest that the production of 15d-PGJ2, which is mediated by cyclooxygenase 2 (COX-2), induces non-alcoholic fatty liver disease (NAFLD) and hepatic insulin (show INS Proteins) resistance by activating peroxisome proliferator-activated receptor gamma (PPARgamma (show PPARG Proteins)) .

  10. results suggest that Cox-2 is involved in the pathogenesis of noise-induced hearing loss; and pharmacological inhibition of Cox-2 has considerable therapeutic potential in noise-induced hearing loss.

Human Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. higher COX-2 expression levels in biopsy specimens may be used to decide re-biopsy in borderline preoperative PSA (show PLAG1 Proteins) levels as well as in the cases with suspicious pathological findings for cancer

  2. short hairpin-mediated silencing of SEMA7A (show SEMA7A Proteins) reveals roles for semaphorin 7a (show SEMA7A Proteins) in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a (show SEMA7A Proteins) expression and suggest that semaphorin 7a (show SEMA7A Proteins) promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor

  3. Bisphenol A (BPA) induced COX-2 expression via nuclear translocation of NF-kappaB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells.

  4. Data show that in colorectal cancer SerpinB3 (show SERPINB3 Proteins), COX-2 and beta-Catenin (show CTNNB1 Proteins) are positively correlated and associated with more advanced tumor stage.

  5. Higher proliferation rate of NKT (show SLC22A6 Proteins) cells was also observed in non-metastatic and highly differentiated Laryngeal Cancer( LC), which was independent of the type of stimulation or treatment. COX-2 inhibition could be regarded as immunotherapy-enhancing tool in patients with LC.

  6. Data indicate that ellagic aicd (EA) down-regulates the expression of COX-2, NF-kappa B (show NFKB1 Proteins), vimentin (show VIM Proteins) and up-regulates the expression of E-cadherin (show CDH1 Proteins) in in pancreatic carcinom PANC-1 cells.

  7. YAP (show YAP1 Proteins) function is required for NF2 (show NF2 Proteins)-null Schwann cell survival, proliferation, and tumor growth in vivo Moreover, YAP (show YAP1 Proteins) promotes transcription of several targets including PTGS2, which codes for COX-2, a key enzyme in prostaglandin biosynthesis, and AREG (show AREG Proteins), which codes for the EGFR (show EGFR Proteins) ligand, amphiregulin (show AREG Proteins).

  8. The aspirin-mediated inactivation of platelets may restore antitumor reactivity by blocking the release of paracrine lipid and protein mediators that induce COX-2 expression in adjacent nucleated cells at sites of mucosal injury. [review]

  9. HULC enhanced the level of ubiquitin-specific peptidase 22 (USP22 (show USP22 Proteins)), which decreased ubiquitin-mediated degradation of COX-2 protein by removing the conjugated polyubiquitin (show UBB Proteins) chains from COX-2 and finally stabilized COX2 protein.

  10. COX-2 expression was significantly increased in wound edge amniotic membrane after fetoscopy compared with controls.

Pig (Porcine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. These findings suggest that nuclear factor kappa B(NF-kappaB (show NFKB1 Proteins)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.

  2. COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.

  3. These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.

  4. Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla

  5. COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.

  6. In porcine vas (show AVP Proteins) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.

  7. expression appears to be positively and negatively regulated by p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined

  8. Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (show IL1B Proteins)-dependent upregulation of COX-2. (Cyclooxygenase 2)

  9. Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.

  10. The effect of EGF (show EGF Proteins) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (show TNF Proteins)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.

Rabbit Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (show IL1B Proteins),COX-2, and TGFbeta1 (show TGFB1 Proteins)

  2. The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2.

  3. Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 vasodilator, prostacyclin.

  4. Local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.

Goat Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. The vesicular gland of castrated goats showed significantly lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Protein Profile

Protein Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.

Alternative names and synonyms associated with Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2)

  • cyclooxygenase-2 (COX-2)
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2)
  • cyclooxygenase-2 (cox-2)
  • cyclooxygenase 2 (cox-2)
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (ptgs2)
  • cytochrome c oxidase subunit II (COX2)
  • olfactory receptor, family 2, subfamily W, member 1-like (LOC782475)
  • prostaglandin-endoperoxide synthase 2 (Ptgs2)
  • CEF147 protein
  • COII protein
  • Cox-2 protein
  • Cox2 protein
  • GRIPGHS protein
  • hCox-2 protein
  • PGG/HS protein
  • PGHS-2 protein
  • PGHS2 protein
  • PHS-2 protein
  • PHSII protein
  • PTGS2 protein
  • TIS10 protein

Protein level used designations for PTGS2

cyclooxygenase-2 , cyclooxygenase 2 , prostaglandin G/H synthase 2 , prostaglandin G/H synthase and cyclooxygenase , prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) , prostaglandin G/H synthase 2-like , PES-2 , PGH synthase 2 , PHS II , glucocorticoid-regulated inflammatory cyclooxygenase , gripghs , macrophage activation-associated marker protein P71/73 , prostaglandin H2 synthase 2 , PGHS-2 , cyclooxygenase 2b , COX-2 , prostaglandin G/H synthase-2 , cyclooxygenase, prostaglandin endoperoxide H synthase-2 , prostaglandin H synthase-2 , cyclooxygenase type 2 , mitogen-inducible PGHS

GENE ID SPECIES
100033836 Equus caballus
100126581 Felis catus
100136025 Oncorhynchus mykiss
100136456 Salmo salar
446781 Xenopus laevis
469616 Pan troglodytes
595089 Xenopus (Silurana) tropicalis
716671 Macaca mulatta
100407639 Callithrix jacchus
100436566 Pongo abelii
807845 Equus caballus
808252 Ovis aries
782475 Bos taurus
19225 Mus musculus
29527 Rattus norvegicus
100135607 Cavia porcellus
5743 Homo sapiens
282023 Bos taurus
791253 Equus caballus
443460 Ovis aries
442942 Canis lupus familiaris
397590 Sus scrofa
100009248 Oryctolagus cuniculus
396451 Gallus gallus
100860905 Capra hircus
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