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whole-mount in situ hybridization and real-time quantitative RT-PCR to identify expression of the zebrafish SCD gene at five different stages of development
Results provide evidence that SCD is a regulator of breast stemness.
these data demonstrate for the first time the involvement of SCD1 in the regulation of the Hippo pathway in lung cancer, and point to fatty acids metabolism as a key regulator of lung cancer stem cells.
High SCD1 expression is associated with resistance to cisplatin in lung cancer.
Results provide evidence that the hepatic BSCL2 (show BSCL2 Proteins) deficiency induces the increase and expansion of lipid droplets potentially via increased SCD1 activity.
high SCD1 expression is an independent prognostic factor for OS in patients with ccRCC. Our data suggest that the expression of SCD1 might guide the clinical decisions for patients with ccRCC.
A relevant link between one-night sleep deprivation , hepatic SCD1 expression and de-novo fatty acid synthesis via epigenetically driven regulatory mechanisms was found.
stearoyl-coenzyme A desaturase 1 has a role in clear cell renal cell carcinoma (show MOK Proteins)
Chronic exposure to chewing tobacco induces carcinogenesis in non-malignant oral epithelial cells and SCD plays an essential role in this process.
This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
The data indicate a direct inhibitory interaction of polyunsaturated fatty acids with LXRalpha (show NR1H3 Proteins), a consequent reduction of SREBP-1 (show SREBF1 Proteins) and of its binding to SCD1 promoter.
E. coli mastitis reduced SCD1 expression in liver and udder.
Here, the association between DGAT1 (show DGAT1 Proteins) K232A, SCD1 A293V, and LEPR (show LEPR Proteins) T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1 (show DGAT1 Proteins), SCD1, and LEPR (show LEPR Proteins) polymorphisms were GC/GC (show GC Proteins), C, and C, respectively. The SCD1 CC genotype was associated with a low cholesterolemic FA content, a high ratio of linolenic acid to cholesterolemic FA, and lower conjugated-linolenic acid and PUFA content.
significant effects of the SCD gene on milk medium- and long-chain unsaturated fatty acids, especially for C14 (show LGALS1 Proteins):1 and C14 (show LGALS1 Proteins) index in dairy cattle
Studied the responsiveness of bovine SCD1 promoter to serum, insulin (show INS Proteins), oleic acid, and NFY transcription factor in BME-UV1 cells.
The results suggest that a mutation of SCD1, but not LEPR or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.
Suppression of CPT1B (show CPT1B Proteins) and induction of SCD and CEBPB (show CEBPB Proteins) by supplemental arginine promotes increased adiposity in Angus steers.
This study showed that milk somatic cells can be used as a source of mRNA to study SCD1 expression in dairy cows, offering a non-invasive alternative to mammary tissue samples obtained by biopsy.
This study presents evidence that there are breed- and diet-induced variations on lipid metabolism in the muscle, which may be, at least partially, modulated by the stearoyl-CoA desaturase (SCD) gene expression levels.
These results provide detailed genetic information for the SREBP1 (show SREBF1 Proteins) signalling pathway and SCD that can be used to change milk fat composition by marker-assisted breeding.
study evaluated the contributions of polymorphisms of FASN (show FASN Proteins) and SCD genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations
Results indicated that the positive effect of the T allele at the SCD gene on monounsaturated fatty acid and of the T allele at the LEPR gene on saturated fatty acid are maintained throughout the growing-finishing period, both in longissimus thoracis and subcutaneous fat.
genetic association study in Duroc gilts/barrows in Spain: Data suggest that T allele in promoter region of SCD (2228T>C) leads to up-regulation of monounsaturated fatty acid content of biceps femoris/ham which is maintained in dry-cured ham.
The study provides evidence that there exists genetic variation in the SCD gene with the potential to increase monounsaturated content in pork.
There was a positive relationship between stearoyl-CoA desaturase (SCD) protein expression in longissimus muscle and monounsaturated fatty acid content, and SCD protein expression and total muscle fatty acid content in Large White x Landrace breeds.
The relationships between a point mutation of SCD and multiple production traits in swine are reported.
The results indicate that the haplotype of the SCD gene has a strong effect on fatty acid composition and melting point of fat.
Stearoyl-CoA desaturase(SCD) has a total of 21 gene polymorphisms in the 21-kb DNA sequence, adn (show CFD Proteins) RT-PCR result indicates that the SCD gene is expressed ubiquitously in tissues.
SCD1 is a key player in the development of alcoholic fatty liver disease.
SCD1 ablation/inhibition decreased cardiac lipid content.
Our data provide evidence that SCD1 has a broad impact on WAT lipid handling by altering TAG composition in a depot-specific manner, reducing FA reesterification, and regulating markers of lipolysis and glyceroneogenesis.
SCD expressed by HSCs promoted liver tumor development in mice.
investigated the effect of genetic ablation of SCD1 in 3T3-L1 adipocytes on membrane microdomain lipid composition at the species-specific level
Splenic effector T cells (CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(-)) from age- and sex-matched wild-type (WT) and Scd1KO mice were isolated by FACS and intraperitoneally administered to Rag1KO mice, which were monitored for the development of colitis. At day 60 postcell transfer, Rag1KO mice that received Scd1KO CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(-) T cells displayed accelerated and exacerbated colitis than mice receiving WT CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(-) T cells.
Scd1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells.
Scd1 Is Regulated by Dbc1 (show DBC1 Proteins) and SirT1 (show SIRT1 Proteins).
Study provides new insights into the critical role of SCD1 as a regulator of adipocyte function and lipid metabolism.
The study reports report the 3.25-A crystal structure of human SCD1 in complex with its substrate, stearoyl-coenzyme A, which defines the new SCD1 dimetal catalytic center and reveals the determinants of substrate binding.
SCD1 and SCD2 function in clathrin-mediated membrane trafficking essential to both cytokinesis and cell expansion.
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
, stearoyl-CoA desaturase 5
, stearoyl-CoA desaturase 1
, delta-9 desaturase
, acyl-CoA delta-11 desaturase/conjugase
, acyl CoA desaturase
, pheromone gland-specific acyl-CoA desaturase
, acyl-CoA desaturase
, stearoyl-CoA desaturase
, Acyl-CoA desaturase
, stearoyl-CoA desaturase (delta-9-desaturase)
, fatty acid desaturase
, predicted protein of HQ0998
, stearoyl-CoA desaturase opposite strand
, stearoyl-coenzyme A desaturase
, acyl-CoA desaturase 2
, delta(9)-desaturase 2
, delta-9 desaturase 2
, fatty acid desaturase 2
, stearoyl-CoA desaturase 2
, stearoyl-Coenzyme A desaturase 2
, acyl-CoA desaturase 1
, delta(9)-desaturase 1
, delta-9 desaturase 1
, fatty acid desaturase 1