BASKET
HELP
Product details for 4-amino Biphenyl DNA antibody
4-amino Biphenyl DNA antibody
Overview
| Antigen: | 4-amino Biphenyl DNA |
| Antibody Type: | Monoclonal |
| Application: | Immunohistochemistry (Frozen Sections) (IHC) (fro), Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (paraffin-embedded Sections) (IHC (p)) |
| Host: | Mouse |
| Quantity: | |
| Price: | 300,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN151875 |
| Availability: | Ships in 7 to 10 days |
Additional Information: 4-amino Biphenyl DNA antibody
| Antigen | 4-amino Biphenyl DNA |
| Immunogen | 4-amino Biphenyl DNA Cellular Location: Nuclear |
| Antibody Type | Monoclonal |
| Format | Purified |
| Isotype | IgG »Matching secondary antibodies |
| Description | 4-amino Biphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as aconstituent of tobacco smoke, in the form of an environmental carcinogen. It ismetabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known asN-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites isdependent on the activation and detoxification of N-acetylation. 4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well asgenetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized thatsmokers may have higher levels of DNA adducts than non-smokers and that the role of4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breasttumorigenesis. The antibody has been used to investigate the role of 4-ABP in thestudy of human breast cancer by measuring 4-ABP-DNA adducts. Synonyms: 4-amino-Biphenyl DNA antibody, 4-AMBP DNA antibody, 4-aminobiphenyl DNAantibody |
| Clone | 4C11 |
| Host | Mouse |
| Specificity | This antibody is specific for 4-amino Biphenyl DNA. All DNAs |
Application Details: 4-amino Biphenyl DNA antibody
| Application | Immunohistochemistry (Frozen Sections) (IHC) (fro), Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (paraffin-embedded Sections) (IHC (p)) |
| Application Notes | This antibody has specifically been used in ELISA. This clone has been shown to workin immunocytochemistry, immunofluorescence, and immunohistochemistry on bothparaffin-embedded and frozen sections. Other applications have not been tested.Suggested working dilutions: *ELISA - (+)Immunohisto/cytochemistry - 1:50-1:100*The investigator should determine the optimal working dilution for a specific application. |
| Concentration | 1.4 mg/ml |
| Buffer | 0.1 ml of Protein G purified mouse ascites [1.4 mg/ml] in PBS containing 0.1% SodiumAzide. |
| Storage | Store at 4 degrees C. Long term (> 6 months) aliquot and store at –20 degrees C. Avoid repeated freeze thaw cycles. |
| Restrictions | For Research Use only |
External Information: 4-amino Biphenyl DNA antibody
| Google Scholar | Find more references for clone 4C11 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen 4-amino Biphenyl DNA (Bioinformatic Harvester (EMBL)) |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
