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A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5 (Human) antibody

Overview

Antigen: A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5
Antibody Type: Polyclonal
Application: Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reactivity: Human
Host: Rabbit
Quantity: 25 ug (1 mg/ml)
Price: 270,00 €   (Plus shipping costs and VAT)
Order number: ABIN143099
Availability: 7 to 10 days until shipment
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Additional Information:  A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5 (Human) antibody

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Antigen A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5
Immunogen Synthetic peptide-KLH conjugated
Reactivity Human
Antibody Type Polyclonal
Format Liquid
Isotype IgG »Matching secondary antibodies
Description ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a met turn, a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.
Host Rabbit

Application Details:  A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5 (Human) antibody

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Application Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Application Notes Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. IHC-P: Use at a dilution of 1/100-1/200.
Format Liquid
Concentration 1 mg/ml
Purity Immunogen affinity purified.
Buffer Phosphate buffered saline, PH 7.7 containing 0.01% sodium azide
Storage Store at 4 C short term, For long term storage aliquot and store at -20 C or below.
Restrictions For research use only

External Information:  A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5 (Human) antibody

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EMBL Harvester Search human, mouse or rat genome for antigen A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif 5 (Bioinformatic Harvester (EMBL))