BRCA1 (phospho S1189) (Human) antibody

Overview

Antigen	BRCA1 (phospho S1189)
Immunogen	Synthetic phospho peptide (Human), which represents a portion of human Breast Cancer Gene 1 around serine 1189.
Reactivity	Human
Antibody Type	Polyclonal
Isotype	IgG »Matching secondary antibodies
Description	BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer.
Host	Rabbit

Application	Western Blotting (WB)
Application Notes	WB: Use at a dilution of 1/2000-1/15000. Predicted molecular weight: 220 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration	1 mg/ml
Purity	Immunogen affinity purified
Buffer	Tris-citrate/phosphate, pH 7-8, 0.1% sodium azide
Storage	Store at 2-8 C.
Restrictions	For research use only

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