CoREST (Human) antibody

Overview

Antigen	CoREST
Immunogen	A synthetic peptide that maps to a region between residues 425 and the C-terminus(residue 482) of human REST (RE1-silencing transcription factor) corepressor using thenumbering given in entry NP_055971.1 (GeneID 23186)
Reactivity	Human
Antibody Type	Polyclonal
Format	Aff - Purified
Description	Brain type II sodium channels are important in neuronal phenotyping and are only seenat high levels in neurons. Studies have shown that CoREST functions as a corepressorfor REST. This interaction between REST and CoREST is accomplished by means of asingle zinc finger binding motif originating from REST. Together, the REST-CoRESTcomplex mediates long term repression of the type II sodium channel gene (1).
Host	Rabbit
Specificity	Human. Other species have not been tested. Reactivity with mouse CoREST isexpected owing to conservation of sequence between this ortholog and human CoRESTat the site to which the epitope maps.

Application	Western Blotting (WB)
Application Notes	This antibody may be used in Western Blot. Immunoprecipitation andimmunohistochemistry have not been tested.Suggested working dilutions: Western Blot1:2,500-1:15,000The investigator should determine the optimal working dilution for a specific application. Positive Control:HeLa nuclear extracts
Concentration	1 mg/ml
Buffer	0.1 ml of affinity purified rabbit antisera [1.0 mg/ml], in Tris-citrate/phosphate (pH 7-8)buffer containing 0.1% sodium azide.
Storage	Store at 4 degrees Celcius.
Restrictions	For Research Use only

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