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Product details for Coronin 1 (Human) antibody
Coronin 1 (Human) antibody
Overview
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| Antigen: | Coronin 1 |
| Antibody Type: | Polyclonal |
| Application: | ELISA, Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat, Bovine |
| Host: | Goat |
| Quantity: | |
| Price: | 388,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN147399 |
| Availability: | 7 to 10 days until shipment |
Additional Information: Coronin 1 (Human) antibody
| Antigen | Coronin 1 |
| Immunogen | Synthetic peptide: KRLDRLEETVQAK, corresponding to amino acids 449-461 of Human Coronin 1. |
| Reactivity | Human, Mouse (Murine), Rat, Bovine |
| Antibody Type | Polyclonal |
| Format | Liquid |
| Isotype | IgG »Matching secondary antibodies |
| Description | Coronin 1 was first isolated from Dictyostelium, but similar proteins have been identified in many species and individual cell types. The coronin-like protein in yeast promotes actin polymerization and also interacts with microtubules. Dictyostelium mutants lacking coronin are impaired in cytokinesis and all actin-mediated processes. Analysis of coronin-GFP (green-fluorescent protein) fusions and knockout mutants shows that coronin participates in the remodelling of the cortical actin cytoskeleton that is responsible for phagocytosis and macropinocytosis. Likewise, in mammalian neutrophils, a coronin-like protein is also associated with the phagocytic apparatus. Coronin 1 binds actin (by similarity) and is found in noninfected macrophages, localised to the cortical microtubule network, in mycobacteria-infected macrophages, progressively relocalized and retained around the mycobacterial phagosomes. Coronin1/TACO is expressed in brain, thymus, spleen, bone marrow and lymph node. Low e |
| Host | Goat |
Application Details: Coronin 1 (Human) antibody
| Application | ELISA, Western Blotting (WB) |
| Application Notes | Peptide ELISA: Use at a dilution of 1/16000. WB: Use at a concentration of 0.25-1 ug/ml. Detects a band of approximately 60 kDa in Molt-4 and Jurkat lysates (predicted molecular weight: 53 kDa according to NP_009005). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.5 mg/ml |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: 0.02% Sodium AzideConstituents: 0.5% BSA, 0.5mg/ml Tris-saline. pH 7.3 |
| Restrictions | For research use only |
External Information: Coronin 1 (Human) antibody
| Google Scholar | Find more references for antigen Coronin 1 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Coronin 1 (Bioinformatic Harvester (EMBL)) |
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