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Product details for FOXO4 (Human) antibody
FOXO4 (Human) antibody
Overview
| Antigen: | FOXO4 |
| Antibody Type: | Polyclonal |
| Application: | Immunofluorescence (IF), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 368,42 $ (Plus shipping costs and VAT, Invoice in EUR) |
| Order number: | ABIN147044 |
| Availability: | 7 to 10 days until shipment |
Additional Information: FOXO4 (Human) antibody
| Antigen | FOXO4 |
| Immunogen | Synthetic peptide, corresponding to C-term amino acids 451-466 with N-terminally added lysine, of Human AFX / FOXO4. |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Liquid |
| Isotype | IgG »Matching secondary antibodies |
| Description | The forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX and FKHRL1) have sequence similarity to the nematode homolog Daf 16, recently shown to mediate signaling via a pathway involving IGFR1, P13-K and Akt. There are three potential Akt phosphorylation sites on the FKHR proteins. One site, FKHR Ser256 is found in the Forkhead domain and the other two are outside this domain. Recent studies show that phosphorylation of FKHR family members by Akt promotes cell survival. Phosphorylation regulates FKHR nuclear translocation and target gene transcription. Insulin also stimulates FKHR phosphorylation at Ser253. |
| Host | Rabbit |
Application Details: FOXO4 (Human) antibody
| Application | Immunofluorescence (IF), Western Blotting (WB) |
| Application Notes | IF: Use at a dilution of 1/1000. This dilution is determined by using paraformaldehyde fixed AFX transfected COS-7 cells. WB: Use at a dilution of 1/2000. This dilution is determined using human AFX expressed in transfected COS-7 cell extracts. Predicted molecular weight: 50 kDa. Staining of AFX is specifically inhibited by the AFX immunizing peptide. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | Batch dependent |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: 15mM Sodium AzideConstituents: 1% BSA, 0.01M PBS. pH 7.4 |
| Restrictions | For research use only |
External Information: FOXO4 (Human) antibody
| Google Scholar | Find more references for antigen FOXO4 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen FOXO4 (Bioinformatic Harvester (EMBL)) |
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