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Product details for I Kappa K alpha (IKKa) (Human) antibody
I Kappa K alpha (IKKa) (Human) antibody
Overview
| Antigen: | I Kappa K alpha (IKKa) (C-term) |
| Antibody Type: | Polyclonal |
| Application: | Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB), Immunoblotting (IB) |
| Reactivity: | Human, Mouse (Murine), Rat |
| Host: | Rabbit |
| Quantity: | |
| Price: | 340,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN116874 |
| Availability: | Ships in 3 to 10 days |
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Additional Information: I Kappa K alpha (IKKa) (Human) antibody
| Antigen | I Kappa K alpha (IKKa) (C-term) |
| Immunogen | IKKa peptide corresponding to the highly conserved C-terminus region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH). |
| Reactivity | Human, Mouse (Murine), Rat |
| Antibody Type | Polyclonal |
| Format | Serum |
| Host | Rabbit |
| Specificity | NFk B comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response and control of cell death. In the cytoplasm NFk B is negatively modulated by the inhibitory proteins Ik B. In turn Ik B is phosphorylated by a cellular kinase complex called IKK. IKK is a heterodimer composed of two kinases: IKK-a and IKK-b that phosphorylate Ik B leading to its degradation and the resulting translocation of NFk B to the nucleus. IKK kinase activity is modulated negatively by pharmaceutical agents such as aspirin and positively by various cellular components such as TNF-a , endotoxins and overexpression of cellular kinases like MEKK1. Aspirin appears to have its effect by inhibiting the binding of ATP to IKK. This product was prepared from monospecific antiserum by delipidation and defibrination. Anti- IKKa may react non-specifically with other proteins. Control peptide will compete only with the specific reaction of antiserum with the IKKa subunit. 1 |
Application Details: I Kappa K alpha (IKKa) (Human) antibody
| Application | Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB), Immunoblotting (IB) |
| Application Notes | Suitable for immunoprecipitation, immunoblotting and ELISA. This product was assayed by immunoblot and found to be reactive against IKKa at a dilution of 1:1000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG [H&,,,L] (Goat). Anti-IKKa is suitable for the detection by immunoblot of human, mouse and rat IKKa showing an 85 kDa band. Optimal titers for other applications should be determined by the researcher. Other applications not tested. |
| Format | Serum |
| Concentration | 80.0 mg/ml (by Refractometry) |
| Buffer | This antibody is supplied as liquid sterile filtered immunoglobulin fraction with 0.01% sodium azide as preservative. |
| Storage | Store vial at -20° C or below prior to opening. Dilute only prior to immediate use. Aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is six (6) months from date of opening product. |
| Restrictions | Research only |
External Information: I Kappa K alpha (IKKa) (Human) antibody
| Google Scholar | Find more references for antigen I Kappa K alpha (IKKa) (C-term) on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen I Kappa K alpha (IKKa) (C-term) (Bioinformatic Harvester (EMBL)) |
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