IL-17E (Human) antibody

Overview


	Antigen:	Interleukin-17E (IL-17E)
	Antibody Type:	Monoclonal
	Application:	Western Blotting (WB)
	Reactivity:	Human, Mouse (Murine)
	Host:	Mouse
	Quantity:	0.1 mg (0.5 mg/ml)
	Price:	300,00 € (Plus shipping costs and VAT)
	Order number:	ABIN121259
	Availability:	Ships in 3 to 10 days

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Additional Information: IL-17E (Human) antibody

Antigen	Interleukin-17E (IL-17E)
Immunogen	A synthetic peptide of amino acids 115-132, obtained from the human IL-17E protein sequence, was used as immunogen.
Reactivity	Human, Mouse (Murine)
Antibody Type	Monoclonal
Format	Purified
Isotype	IgG2b »Matching secondary antibodies
Clone	68C1039
Host	Mouse
Specificity	Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E (2). IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis (3), multiple sclerosis (4), and promotion of tumor growth (5). IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al (6) and Lee, et al. (2) and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. Reacts with Mouse, Human.

Application Details: IL-17E (Human) antibody

Application	Western Blotting (WB)
Application Notes	Western blot analysis (2.0 ug/ml, positive control: mouse testes). In mouse testes, a 16 kDa band is observed. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration	0.5 mg/ml
Buffer	This antibody is supplied as liquid IgG fraction, purified on Protein G, in PBS containing 0.02% sodium azide as preservative.
Storage	Store the antibody at 4°C for one month or at –20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area	Cytokines, Receptors, Inflammation
Restrictions	Research only

Publications: IL-17E (Human) antibody

Publications

Lee, Ho, Maruoka et al.:
"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1."
In: The Journal of biological chemistry , Vol. 276, Issue 2, pp. 1660-4, 2001/01 (PubMed)

Li, Chen, Huang et al.:
"Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
In: Proceedings of the National Academy of Sciences of the United States of America , Vol. 97, Issue 2, pp. 773-8, 2000/01 (PubMed)

Matusevicius, Kivisaekk, He et al.:
"Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis."
In: Multiple sclerosis (Houndmills, Basingstoke, England) , Vol. 5, Issue 2, pp. 101-4, 1999/01 (PubMed)

Shalom-Barak, Quach, Lotz:
"Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB."
In: The Journal of biological chemistry , Vol. 273, Issue 42, pp. 27467-73, 1998/01 (PubMed)

Shi, Ullrich, Zhang et al.:
"A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
In: The Journal of biological chemistry , Vol. 275, Issue 25, pp. 19167-76, 2000/01 (PubMed)

Tartour, Fossiez, Joyeux et al.:
"Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice."
In: Cancer research , Vol. 59, Issue 15, pp. 3698-704, 1999/01 (PubMed)

Images: IL-17E (Human) antibody

Western blot analysis of IL-17E in mouse testis lysate using ABIN121259. Ten microgram of lysate was used per lane.

Image for IL-17E (Human) antibody (1)

External Information: IL-17E (Human) antibody

Google Scholar	Find more references for clone 68C1039 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen Interleukin-17E (IL-17E) (Bioinformatic Harvester (EMBL))