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Product details for JunB (Mouse (Murine)) antibody
JunB (Mouse (Murine)) antibody
Overview
| Antigen: | Jun B |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Mouse (Murine) |
| Host: | Rabbit |
| Quantity: | |
| Price: | 330,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN122909 |
| Availability: | Ships in 3 to 10 days |
Additional Information: JunB (Mouse (Murine)) antibody
| Antigen | Jun B |
| Immunogen | Synthetic Peptide: D(45) P Y R G L K G P G A R G P G P E(61). |
| Reactivity | Mouse (Murine) |
| Antibody Type | Polyclonal |
| Format | Purified |
| Host | Rabbit |
| Specificity | Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication path ways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2. Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the .leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes. ABIN122909 detects JunB from mouse cells. ABIN122909 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing JunB from both uninduced and induced L929 cells. ABIN122909 immunizing peptide corresponds to amino acid residues 45-61 of mouse JunB. |
Application Details: JunB (Mouse (Murine)) antibody
| Application | Western Blotting (WB) |
| Application Notes | Western Blot: 10 ug/ml. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user. |
| Buffer | This antibody is supplied as lyophilized, purified rabbit IgG. Reconstitute with PBS. |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Restrictions | Research only |
External Information: JunB (Mouse (Murine)) antibody
| Google Scholar | Find more references for antigen Jun B on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Jun B (Bioinformatic Harvester (EMBL)) |
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