Product details for  Jun (Human) antibody
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Jun (Human) antibody

Overview

Antigen: Jun
Antibody Type: Polyclonal
Application: Western Blotting (WB), Immunohistochemistry (IHC)
Reactivity: Human, Mouse (Murine), Rat
Host: Rabbit
Quantity: 100 µg
Price: 266,00 €   (Plus shipping costs and VAT)
Order number: ABIN131235
Availability: 7 to 10 days until shipment
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Additional Information:  Jun (Human) antibody

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Antigen Jun
Reactivity Human, Mouse (Murine), Rat
Antibody Type Polyclonal
Isotype IgG, Ig »Matching secondary antibodies
Description Extracellular stimuli such as growth factors and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation at Ser63/73 renders c-Jun non-responsive to mitogenic and stress induced signaling pathways. JNK (c-jun N-terminal Kinase) binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. The activity of JNK is stimulated by the same signals that activate c-Jun.
Host Rabbit
Specificity Recognizes c-Jun in samples of human, mouse, and rat origin. The antibody only recognizes c-Jun, and will not detect the endogenous levels of Jun B or Jun D.

Application Details:  Jun (Human) antibody

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Application Western Blotting (WB), Immunohistochemistry (IHC)
Application Notes The antibody can be used for Western blot analysis (1 µg/ml) and immunohistochemistry (20-40 µg/ml). However, the optimal conditions should be determined individually.
Buffer Supplied as 100 µg (0.5 mg/ml) affinity purified rabbit anti-c-Jun polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
Restrictions For Research Use Only

Publications:  Jun (Human) antibody

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Publications Binetruy, Smeal, Karin:
"Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain."
In: Nature , Vol. 351, Issue 6322, pp. 122-7, 1991/01 (PubMed)

Derijard, Hibi, Wu et al.:
"JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain."
In: Cell , Vol. 76, Issue 6, pp. 1025-37, 1994/01 (PubMed)

External Information:  Jun (Human) antibody

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Google Scholar Find more references for antigen Jun on Google Scholar™
EMBL Harvester Search human, mouse or rat genome for antigen Jun (Bioinformatic Harvester (EMBL))