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K-sam (KATO-III cells derived stomach cancer amplified gene) (Human) antibody

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Antigen: K-sam (KATO-III cells derived stomach cancer amplified gene)
Antibody Type: Polyclonal
Application: Immunohistochemistry (IHC), Western Blotting (WB)
Reactivity: Human
Host: Rabbit
Quantity: 100 µg
Price: 315,00 €   (Plus shipping costs and VAT)
Order number: ABIN180179
Availability: 10 days until shipment
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Additional Information:  K-sam (KATO-III cells derived stomach cancer amplified gene) (Human) antibody

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Antigen K-sam (KATO-III cells derived stomach cancer amplified gene)
Immunogen Synthetic peptide for a part of Human K-sam Purification: Affinity Purified with synthetic peptide
Reactivity Human
Antibody Type Polyclonal
Isotype IgG »Matching secondary antibodies
Description The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified, the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers.
Host Rabbit

Application Details:  K-sam (KATO-III cells derived stomach cancer amplified gene) (Human) antibody

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Application Immunohistochemistry (IHC), Western Blotting (WB)
Application Notes This antibody can be stained in formalin fixed paraffin embedded tissues. The staining intensity may be reinforced by microwave treatment. The optimal dilution is 2 ­ 5 ug/ml, however, each laboratories should optimize the dilution rate. ·F This antibody can be used for western blotting in concentration of 1 - 5 ug/ml. Reactivity:React with Scirrhous carcinoma
Purification Antigen peptide
Buffer Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1 ml distilled water will be added to the product
Storage Lyophilized product, 5 years at 2 ­ 8 C : Solution, 2 years at ­20 C
Restrictions For Research Use only

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