NMDA Receptor 2A (Human) antibody

Overview

Antigen	NMDA Receptor 2A
Immunogen	This product was raised against a c-terminal fusion protein representing amino acids 1253-1391of rat NMDAR2A.
Reactivity	Human, Mouse (Murine), Rat
Antibody Type	Polyclonal
Format	Liquid
Description	The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.
Host	Rabbit
Specificity	Is specific to NMDAR2A. The specificity is defined based on its specific immunolabeling of the 2A subunit band in Western blots. This labeling is blocked by preincubation with the antigen.

Application Notes	For WB: Use at a dilution of 1:500 (ECL). Western blotting where it recognizes a band at ~50 kDa representing ETR-3. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Concentration	0.2 mg/ml
Purity	Affinity purified
Buffer	N/A
Storage	After reconstitution store at -20 C. Avoid repeated freeze-thaw cycles.
Restrictions	For research use only

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