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Product details for NR2B pTyr1336 (Human) antibody
NR2B pTyr1336 (Human) antibody
Overview
| Antigen: | NMDA Receptor 2B (NR2B) pTyr1336 |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat |
| Host: | Rabbit |
| Quantity: | |
| Price: | 330,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN152632 |
| Availability: | Ships in 7 to 10 days |
Additional Information: NR2B pTyr1336 (Human) antibody
| Antigen | NMDA Receptor 2B (NR2B) pTyr1336 |
| Immunogen | Phosphopeptide corresponding to amino acid residues surrounding thephospho-Tyr1336 of the NR2B subunit of the rat NMDA Receptor. |
| Reactivity | Human, Mouse (Murine), Rat |
| Antibody Type | Polyclonal |
| Format | Aff - Purified |
| Description | The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate andalpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known askainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate(NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essentialrole in memory, neuronal development and it has also been implicated in severaldisorders of the central nervous system including Alzheimer's, epilepsy and ischemicneuronal cell death. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to becloned. The NR1 protein can form NMDA activated channels when expressed inXenopus oocytes but the currents in such channels are much smaller than those seen insitu. Channels with more physiological characteristics are produced when the NR1subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2Bsubunit of the NMDARs is phosphorylated by cyclin dependent kinase-5 (cdk5) atSer1252 in vitro and in intact cells and Ser1252 phosphorylation upregulates NMDAreceptor channel activity. The phosphorylation at this site may also play a key role in ischemic cell death. (1-6) Synonyms: Glutamate [NMDA] receptor subunit epsilon 2 [Precursor] antibody, N-methylD-aspartate receptor subtype 2B antibody, NR2B antibody, NMDAR2B antibody,N-methyl-D-aspartate receptor subunit 3 antibody, NR3 antibody, hNR3 antibody |
| Host | Rabbit |
| Specificity | Specific for ~180k NMDAR NR2B subunit protein phosphorylated atTyr1336. Immunolabeling of the NMDAR NR2B subunit band is blocked byl-phosphatase treatment. Human, mouse and rat based on 100% antigen sequence homology. |
Application Details: NR2B pTyr1336 (Human) antibody
| Application | Western Blotting (WB) |
| Application Notes | WB - 1:1,000*The investigator should determine the optimal working dilution for a specific application. This antibody has been tested in Western blot on rat brain hippocampal lysate, detectinga band ~180 kDa. No other applications have been tested.Recommended Starting |
| Buffer | 0.1 ml of affinity purified rabbit sera. Concentration is unknown. Adequate amount ofmaterial to conduct 10-mini Western blots. 10 mM Hepes (pH7.5), 150 mM NaCl, 100 ug/ml BSA and 50% glycerol |
| Storage | Store at -20 degrees C. Stable for 1 year. |
| Restrictions | For Research Use only |
External Information: NR2B pTyr1336 (Human) antibody
| Google Scholar | Find more references for antigen NMDA Receptor 2B (NR2B) pTyr1336 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen NMDA Receptor 2B (NR2B) pTyr1336 (Bioinformatic Harvester (EMBL)) |
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