Neurturin (a.a. 178-193) antibody

Overview

Antigen:	Neurturin (a.a. 178-193)
Antibody Type:	Polyclonal
Application:	Western Blotting (WB)
Host:	Rabbit
Quantity:	100ug (Lot specific)
Price:	478,00 € (Plus shipping costs and VAT)
Order number:	ABIN237857
Availability:	3-5 Business Days

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Additional Information: Neurturin (a.a. 178-193) antibody

Antigen	Neurturin (a.a. 178-193)
Immunogen	A peptide corresponding to amino acids 178 to 193 of human neurturin.(1)
Antibody Type	Polyclonal
Format	Affinity Purified, Liquid
Description	Rabbit anti Neurturin (178-193) Rabbit Antibody to Human Neurturin, amino acids 178-193
Host	Rabbit
Specificity	Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin (1,2). Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNR alpha (3,4) The cDNAs encoding NTNR alpha from human, rat, chicken and mouse have been cloned recently (3-8) and termed GDNFR beta, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR alpha-2 recently.(9) NTN bends to and forms a complex with GFR alpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

Application Details: Neurturin (a.a. 178-193) antibody

Application	Western Blotting (WB)
Application Notes	Suitable for use in Western blot. An approximate 14kDa band of the full length recombinant NTN was detected. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Concentration	Lot specific
Purification	Immunoaffinity chromatography
Buffer	PBS Preservative: 0.02% Sodium azide
Storage	Store at 2-8°C for up to one year.Warnings: This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1 – 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains..
Restrictions	For Research Use Only

Publications: Neurturin (a.a. 178-193) antibody

Publications

Baloh, Tansey, Golden et al.:
"TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret."
In: Neuron , Vol. 18, Issue 5, pp. 793-802, 1997/01 (PubMed)

Buj-Bello, Adu, Pinon et al.:
"Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase."
In: Nature , Vol. 387, Issue 6634, pp. 721-4, 1997/01 (PubMed)

Heuckeroth, Kotzbauer, Copeland et al.:
"Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3."
In: Genomics , Vol. 44, Issue 1, pp. 137-40, 1997/01 (PubMed)

Klein, Sherman, Ho et al.:
"A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor."
In: Nature , Vol. 387, Issue 6634, pp. 717-21, 1997/01 (PubMed)

Sanicola, Hession, Worley et al.:
"Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins."
In: Proceedings of the National Academy of Sciences of the United States of America , Vol. 94, Issue 12, pp. 6238-43, 1997/01 (PubMed)

Suvanto, Wartiovaara, Lindahl et al.:
"Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha."
In: Human molecular genetics , Vol. 6, Issue 8, pp. 1267-73, 1997/01 (PubMed)

Wang, Ni, Jiang et al.:
"Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B: a novel receptor for members of glial cell line-derived neurotrophic factor family of neurotrophic factors."
In: Neuroscience , Vol. 83, Issue 1, pp. 7-14, 1998/01 (PubMed)

External Information: Neurturin (a.a. 178-193) antibody

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EMBL Harvester	Search human, mouse or rat genome for antigen Neurturin (a.a. 178-193) (Bioinformatic Harvester (EMBL))