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Product details for Qa.m2 (Mouse) antibody
Qa.m2 (Mouse) antibody
Overview
| Antigen: | Qa.m2 |
| Antibody Type: | Monoclonal |
| Application: | Cytotoxicity Test (CyTox) |
| Reactivity: | Mouse (Murine) |
| Host: | Mouse |
| Quantity: | |
| Price: | 261,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN133785 |
| Availability: | 7 to 10 days until shipment |
Additional Information: Qa.m2 (Mouse) antibody
| Antigen | Qa.m2 |
| Immunogen | . Fusion Partner: P3-NSI/1-Ag4(NS-1) . DONOR: C57BL/6 |
| Reactivity | Mouse (Murine) |
| Antibody Type | Monoclonal |
| Format | Ascitic fluid (lyophilized) |
| Isotype | IgG2b »Matching secondary antibodies |
| Description | The Qa region, so named because of the closely linked Qa 1-9 loci, is situated on murine chromosome 17 between the H-2D and T1a loci. These Qa loci code for cell surface alloantigens expressed on some lymphoid and myeloid cells. (3) Their expression appears to be controlled by a gene or genes closely linked to the H-2D locus (2) and they have been identified as being structurally related to the murine H-2 antigens. Although no functional role for Qa antigens has been determined, the restricted and differential distribution of Qa determinants on hemopoietic and lymphoid cells raises the possibility that they may not be simply differentiation markers but may play a role in hematopoetic differentiation. (4) anti-mouse Qa.m2 monoclonal antibody detects the Qa.m2 antigenic determinant on the Qa-2 molecule. The Qa-2 molecule has been identified as a two-chain structure composed of a 39,000 d heavy chain and a 12,000 d light chain which is B2 microglobulin. (The heavy chain is readily distinguished from that of H-2.) The Qa.m2 antigen has a wide representation on hematopoeitic cells. It is however, found predominantly on peripheral T cells (cytotoxic and helper T cells) but was present on only 10% of thymus cells. Subpopulations of B cells (approximately 25% of all B cells) and bone marrow cells (15-20%) are also reactive. Qa.m2 was also detected on megakaryocyte colony-forming cells (MEG-CFC) but not on granulocyte- macrophage, erythroid or eosinophil colonies. (5) In addition, the Qa.m2 is a marker of T cell differentiation, as it is selectively expressed on functional T cells. (4) The control of Qa-2 antigen expression and of other Qa antigens by the H-2 region may reflect a control mechanism of functional T cell differentiation and ontogeny in developing T lymphocytes. Thus, although the role of the Qa-2 antigen is unclear, antibodies to this antigen may be useful tools for separating functionally distinct subpopulations of lymphocytes and resolving pathways of differentiation. It may prove to be a useful marker in the study of B lymphocyte differentiation as well as differentiation of certain T cell functional populations. -2- |
| Host | Mouse |
| Specificity | Mouse Qa.m2 |
Application Details: Qa.m2 (Mouse) antibody
| Application | Cytotoxicity Test (CyTox) |
| Concentration | CELL CONCENTRATION: 1 x 10 cells per test. 1:500 |
| Restrictions | For Research Use only |
External Information: Qa.m2 (Mouse) antibody
| Google Scholar | Find more references for antigen Qa.m2 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Qa.m2 (Bioinformatic Harvester (EMBL)) |
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