RIT2 (Human) antibody

Overview

Antigen	RIT2
Immunogen	Recombinant His-tagged full length protein (Human).
Reactivity	Human
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgG »Matching secondary antibodies
Description	The Ras super-family comprises a group of structurally related low molecular weight (20-30 kDa) proteins, which bind GTP or GDP and exhibit a low intrinsic GTPase activity. They are involved in signal transduction and the regulation of a variety of cellular processes, including cell growth, transformation, differentiation and morphogenesis, nucleocytoplasmic transport, and apoptosis. Ras proteins promote cancer by disrupting the normal controls of cell proliferation and differentiation. All Ras subgroups (Ras, Rho, Rab, Ran, and ADP ribosylation factor) contain five highly conserved domains (G1-G5) and act as molecular switches by alternating between an active GTP-bound form and an inactive GDP-bound form. Rit2 (Ras-like protein in neurons) and Rit1 (Ras-like protein in tissues) share 50% homology to Ras. Both contain the five highly conserved domains (G1-G5), bind GTP in vitro, and are membrane-associated. However, both lack a CAAX box and their mechanism of membrane association is
Host	Rabbit
Specificity	Recognizes human recombinant and native Rit2 protein.Cross-reacts slightly with other Ras proteins.

Application	Western Blotting (WB)
Application Notes	WB: Use at a concentration of 5-10 ug/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Format	Liquid
Concentration	1 mg/ml
Purity	IgG fraction
Buffer	Preservative: 0.08% Sodium AzideConstituents: PBS. pH 7.3
Restrictions	For research use only

Google Scholar	Find more references for antigen RIT2 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen RIT2 (Bioinformatic Harvester (EMBL))