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Antigen
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RNA Polymerase 2
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Gene ID
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5430
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Immunogen
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The epitope recognized maps to the C-terminal repeat of human RNA Polymerase II(GeneID 5430).
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Reactivity
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Human
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Antibody Type
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Polyclonal
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Format
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Aff - Purified
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Description
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using thefour ribonucleoside triphosphates as substrates. hRPB9 is a subunit unique to RNA polymerase II, although it has sequence homologuesin RNA polymerases I and III. The gene for Rpb9 is not essential for yeast cell viability,but is essential in Drosophila. hRPB9 has roles in both transcription initiation andtranscription elongation. In the initiation reaction it is necessary for accurate start siteselection. In the elongation reaction, RPB9, along with TFIIS facilitates the conversion ofan arrest-competent conformation to a read-through competent conformation. RNApolymerase II lacking the RPB9 subunit uses alternate transcription initiation sites invitro and in vivo and is unable to respond to the transcription elongation factor TFIIS invitro. A role in the modulation of initiation and elongation is consistent with thelocalization of RPB9 in the three-dimensional structure of yeast RNA polymerase II.RPB9 is located at the tip of the so-called "jaws" of the enzyme, which isthought to function by clamping the DNA downstream of the active site. RPB9comprises two zinc ribbon domains joined by a conserved linker region. The C-terminalzinc ribbon is similar in sequence to that found in TFIIS. Synonyms: RPol2 antibody, RPol-2 antibody, RnaPol2 antibody, RnaPol-2 antibody, PolR2antibody, PolR-2 antibody, RNA Polymerase II antibody, POLRA antibody, Polymerase(RNA) II (DNA directed) Polypeptide A antibody, RpIILS antibody, DNA-Directed RNAPolymerase II largest subunit antibody, hRPB220 antibody, RNA Polymerase II 220 kDasubunit antibody
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Host
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Rabbit
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Specificity
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This antibody cross-reacts with human. Other species have not been tested.
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