Rab27A/B (Human) antibody

Overview


	Antigen:	Rab27A/B
	Antibody Type:	Polyclonal
	Application:	Western Blotting (WB)
	Reactivity:	Human
	Host:	Rabbit
	Quantity:	100 µg
	Price:	315,00 € (Plus shipping costs and VAT)
	Order number:	ABIN180234
	Availability:	10 days until shipment

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Additional Information: Rab27A/B (Human) antibody

Antigen	Rab27A/B
Immunogen	Recombinant Rab27B protein
Reactivity	Human
Antibody Type	Polyclonal
Isotype	IgG »Matching secondary antibodies
Description	Small GTPase Rab is a large family of membrane trafficking proteins that are conserved in all eukaryotic cells. More than 60 Rab isoforms have been reported in mice and humans, and they are believed to regulate various steps (or various types) of organelle transport. The Rab27 subfamily is phylogenetically similar to the Rab3 subfamily, and two Rab27 isoforms, Rab27A and Rab27B, are present in mice and humans. Mutations in the RAB27A gene cause human Griscelli syndrome, which is characterized by pigment dilution and immunodeficiency. The GTP-bound activated form of Rab27A regulates melanosome transport in melanocytes and secretory granule exocytosis (e.g., insulin secretion) through interaction with a specific effector molecule (e.g., Synaptotagmin-like protein (Slp) and Slac2). Rab27B is also expressed on secretory granules, the same as Rab27A, and regulates their exocytosis (e.g., amylase release from rat parotid acinar cells)
Host	Rabbit
Specificity	Cross-reacts with mouse and rat Rab27A/B. Does Does not crossreact with the Rab3 subfamily

Application Details: Rab27A/B (Human) antibody

Application	Western Blotting (WB)
Application Notes	This antibody can be used for western blotting in concentration of about 1~5g/mL.
Purification	Recombinant human Rab27B
Buffer	Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 ml distilled water will be added to the product, then its concentration comes to 100 ug/ml
Storage	Lyophilized product, 5 years at 2 8 C : Solution, 2 years at 20 C
Restrictions	For Research Use only

Publications: Rab27A/B (Human) antibody

Publications

Kesari, Fukuda, Knoblach et al.:
"Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset."
In: The American journal of pathology , Vol. 173, Issue 5, pp. 1476-87, 2008/01

Kesari, Fukuda, Knoblach et al.:
"Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset."
In: The American journal of pathology , Vol. 173, Issue 5, pp. 1476-87, 2008/01 (PubMed)

Images: Rab27A/B (Human) antibody

Image for Rab27A/B (Human) antibody (1)

External Information: Rab27A/B (Human) antibody

Google Scholar	Find more references for antigen Rab27A/B on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen Rab27A/B (Bioinformatic Harvester (EMBL))