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Product details for TSC1/Hamartin (T1149) (Human) antibody
TSC1/Hamartin (T1149) (Human) antibody
Overview
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| Antigen: | TSC1/Hamartin (T1149) |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN195469 |
| Availability: | 10 days until shipment |
Additional Information: TSC1/Hamartin (T1149) (Human) antibody
| Antigen | TSC1/Hamartin (T1149) |
| Immunogen | The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS) |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Affinity purified |
| Isotype | IgG »Matching secondary antibodies |
| Description | TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa (ref. 1). Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor (ref. 2). TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin (ref. 3), a product of another tumor-suppressor gene TSC2 in cytoplasm (ref. 4). The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway (ref. 5). Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division. |
| Host | Rabbit |
| Specificity | Crossreactivities with mouse |
Application Details: TSC1/Hamartin (T1149) (Human) antibody
| Application | Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
| Application Notes | This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 5 ?g /mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 1 - 5 ?g /mL. |
| Purification | Purified with antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 |
| Storage | Lyophilized product, 5 years at 2 – 8 ?. Solution, 2 years at –20 ?. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml) |
| Research Area | Cancer, Diabetes |
| Restrictions | For Research Use only |
External Information: TSC1/Hamartin (T1149) (Human) antibody
| Google Scholar | Find more references for antigen TSC1/Hamartin (T1149) on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen TSC1/Hamartin (T1149) (Bioinformatic Harvester (EMBL)) |
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