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Product details for alpha B Crystallin (phospho S45) (Human) antibody
alpha B Crystallin (phospho S45) (Human) antibody
Overview
| Antigen: | Alpha B Crystallin (phospho S45) |
| Antibody Type: | Polyclonal |
| Application: | Immunofluorescence (IF), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat, Bovine |
| Host: | Rabbit |
| Quantity: | |
| Price: | 388,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN150300 |
| Availability: | 7 to 10 days until shipment |
Additional Information: alpha B Crystallin (phospho S45) (Human) antibody
| Antigen | Alpha B Crystallin (phospho S45) |
| Immunogen | Synthetic peptide: LSpPFYLRPPSF, corresponding to amino acids 44-54 of Human Crystallin (alpha B). |
| Reactivity | Human, Mouse (Murine), Rat, Bovine |
| Antibody Type | Polyclonal |
| Isotype | IgG »Matching secondary antibodies |
| Description | Lens proteins consist almost entirely of Crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha Crystallin is the largest of the crystallins and is composed of 2 primary gene products, alpha A and alpha B. There are at least 5 different proteins comprising the beta Crystallins. The gamma Crystallins are monomeric, but there are at least 5 gamma Crystallins identified in bovine and rat lens. Alpha Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha Crystallin occur in response to cellular stress and may serve a |
| Host | Rabbit |
| Specificity | This antibody does not detect the unphosphorylated form of the protein. |
Application Details: alpha B Crystallin (phospho S45) (Human) antibody
| Application | Immunofluorescence (IF), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Application Notes | IF: Use at a concentration of 5 ug/ml. IHC-P: Use at a concentration of 8 ug/ml. WB: Use at a concentration of 0.5 ug/ml. Detects a band of approximately 20 kDa representing recombinant bovine phospho-alpha-B crystallin (Ser45). Immunofluorescence staining of phospho-alpha-B crystallin (Ser45) in U373 MG cells results in cytoplasmic staining. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: 0.05% Sodium AzideConstituents: PBS, 30mg/ml BSA |
| Restrictions | For research use only |
External Information: alpha B Crystallin (phospho S45) (Human) antibody
| Google Scholar | Find more references for antigen alpha B Crystallin (phospho S45) on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen alpha B Crystallin (phospho S45) (Bioinformatic Harvester (EMBL)) |
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