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Product details for alpha T enin (Human) antibody
alpha T enin (Human) antibody
Overview
| Antigen: | Alpha T enin |
| Antibody Type: | Monoclonal |
| Application: | Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunoprecipitation (IP), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 307,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN143846 |
| Availability: | 7 to 10 days until shipment |
Additional Information: alpha T enin (Human) antibody
| Antigen | Alpha T enin |
| Immunogen | A synthetic peptide corresponding to amino acids 164-177 of the human alpha T catenin protein including an additional N-terminal cysteine (CVANKSDLQKTYQKL) coupled to keyhole limpet hemocyanin. |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG2a »Matching secondary antibodies |
| Description | Catenins are proteins that connect cadherin/b-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alpha T catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alpha T catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alpha T catenin can functionally restore cell-cell adhesion in colon cancer cells lacking a-catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other a-catenins to which it shows an overall amino acid identity of 57%. In cells transfected with a T-catenin cDNA, interaction with b-catenin was demonstrated by co-immunoprecipitation. |
| Clone | 892_24D2S |
| Host | Mouse |
| Specificity | Does not show any cross reaction with alpha E-catenin or alpha N-catenin in western blot analysis. |
Application Details: alpha T enin (Human) antibody
| Application | Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunoprecipitation (IP), Western Blotting (WB) |
| Application Notes | Suitable for immunofluorescence (acetone-fixed cells), immunocytochemistry (methanol and paraformaldehyde-fixed cells, followed by permeabilisation in 0.2% Triton-X 100 for 2 min), immunoprecipitation and immunoblotting. |
| Concentration | 1 mg/ml |
| Purity | Protein A affinity purified. |
| Buffer | Preservative: 0.09% Sodium Azide, Constituents: PBS |
| Storage | Store at 4 C. Aliquot and store at -20 C long-term. |
| Restrictions | For research use only |
External Information: alpha T enin (Human) antibody
| Google Scholar | Find more references for clone 892_24D2S on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen alpha T enin (Bioinformatic Harvester (EMBL)) |
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