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Product details for Alpha2, 6-Sialyltransferase (M2) (Human) antibody

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Alpha2, 6-Sialyltransferase (M2) (Human) antibody

Overview


	Antigen:	Alpha2, 6-Sialyltransferase (M2)
	Antibody Type:	Polyclonal
	Application:	Western Blotting (WB)
	Reactivity:	Human, Mouse, Rat
	Host:	Rabbit
	Quantity:	100ug
	Price:	315,00 € (Plus shipping costs and VAT)
	Order number:	ABIN195493
	Availability:	10 days until shipment

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Additional Information: Alpha2, 6-Sialyltransferase (M2) (Human) antibody

Antigen	Alpha2, 6-Sialyltransferase (M2)
Immunogen	Synthetic peptide of a part of alpha2, 6-sialyltransferase (NSQLVTTEKRFLKDSL) (the part common to human, mouse and rat)
Reactivity	Human, Mouse, Rat
Antibody Type	Polyclonal
Format	Affinity purified
Isotype	IgG »Matching secondary antibodies
Description	The histopathological picture of Alzheimer’s disease is characterized by senile plaques and neurofibrillary tangles, and because the senile plaques form first, they are considered the initial lesion. Senile plaques are known to be formed by accumulation of ?-amyloid peptide (A?). A? peptide is produced by the cleavage of amyloid precursor protein (APP) by two types of proteolytic enzymes. The first cleavage is performed by ?-secretase (BACE1), and the second ?-secretase. It is thought that their inhibitors may be capable of serving as safe drugs for the treatment of Alzheimer’s disease. In recent years a glycosyltransferase involved in the biosynthesis of sugar chains (?2, 6-sialyltransferase) has also been shown to be cleaved by BACE1. The cleavage site was identified at the same time, and as a result it was demonstrated that in rats it produces cleavaged-type ?2, 6-sialyltransferase (E41 Form). This product is purified antibody which can detect human, mouse or rat ?2, 6-sialyltransferase whether or not it is cleavaged.
Host	Rabbit
Specificity	Reacts with Human, Mouse, Rat alpha2, 6-sialyltransferase

Application Details: Alpha2, 6-Sialyltransferase (M2) (Human) antibody

Application	Western Blotting (WB)
Application Notes	Western blotting in concentration of 1 – 5ug/mL
Purification	Purified with antigen peptide
Buffer	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage	Lyophilized product, 5 years at 2 – 8°C. Solution, 2 years at –20 °C. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml)
Research Area	Alzheimer's Disease
Restrictions	For Research Use only

Publications: Alpha2, 6-Sialyltransferase (M2) (Human) antibody

Publications

Kitazume, Saido, Hashimoto:
"[Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase]"
In: Seikagaku. The Journal of Japanese Biochemical Society , Vol. 74, Issue 9, pp. 1180-3, 2002/01 (PubMed)

Kitazume-Kawaguchi, Dohmae, Takio et al.:
"The relationship between ST6Gal I Golgi retention and its cleavage-secretion."
In: Glycobiology , Vol. 9, Issue 12, pp. 1397-406, 2000/01 (PubMed)

Kitazume, Tachida, Oka et al.:
"Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase."
In: Proceedings of the National Academy of Sciences of the United States of America , Vol. 98, Issue 24, pp. 13554-9, 2001/01 (PubMed)

Kitazume, Tachida, Oka et al.:
"Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1)."
In: The Journal of biological chemistry , Vol. 278, Issue 17, pp. 14865-71, 2003/01 (PubMed)

Images: Alpha2, 6-Sialyltransferase (M2) (Human) antibody

Image for Alpha2, 6-Sialyltransferase (M2) (Human) antibody (1)

External Information: Alpha2, 6-Sialyltransferase (M2) (Human) antibody

Google Scholar	Find more references for antigen alpha2, 6-Sialyltransferase (M2) on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen alpha2, 6-Sialyltransferase (M2) (Bioinformatic Harvester (EMBL))