c-Abl (phospho Y245) (Human) antibody

Overview

Antigen	C-Abl (phospho Y245)
Immunogen	Synthetic phospho peptide (Human) derived from a region of human c-Abl that contains tyrosine 245. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, known as 1a and 1b (the more commonly used form). The corresponding p
Reactivity	Human, Mouse (Murine)
Antibody Type	Polyclonal
Isotype	IgG »Matching secondary antibodies
Description	C-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor(PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein BCR/ABL. Tyrosine 245 is involved in the activation of c-Abl kinase activity, and phosphorylated by Src after PDGF stimulation.
Host	Rabbit

Application	Western Blotting (WB)
Application Notes	WB: Use at a concentration of 0.1-1.0 ug/ml. Detects a band of approximately 146 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration	0.5 mg/ml
Purity	Immunogen affinity purified
Buffer	Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA. pH 7.3
Restrictions	For research use only

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