c-Abl (phospho Y412) (Human) antibody

Overview

Antigen	C-Abl (phospho Y412)
Immunogen	The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human c-Abl 1b that contains tyrosine 412. Note: there are two widely expressed forms of c-Abl produced by alternative splicing, designated 1b (the more c
Reactivity	Human, Mouse (Murine)
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgG »Matching secondary antibodies
Description	C-Abl is a 140-150 kDa non-receptor protein tyrosine kinase whose precise functions are not known, but roles for Abl in growth factor and integrin signaling, cell cycle regulation, cytoskeletal reorganization, neurogenesis, and responses to DNA damage and oxidative stress have been suggested. c-Abl kinase activity is increased in vivo by diverse physiological stimuli including ionizing radiation, entry into S phase, integrin activation, and platelet-derived growth factor (PDGF) stimulation. c-Abl contains various protein binding domains that appear to enable it to regulate the functions of many proteins by forming complexes, most notably three isoforms of the oncogenic protein Bcr/Abl. c-Abl becomes fully activated by sequential phosphorylation of tyrosines 412 and 245.
Host	Rabbit

Application	Western Blotting (WB)
Application Notes	WB: Use at a concentration of 0.1-1.0 ug/ml. Detects a band of approximately 140 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Format	Liquid
Concentration	0.5 mg/ml
Purity	Immunogen affinity purified
Buffer	Preservative: 0.05% Sodium AzideConstituents: PBS (without Mg2+ and Ca2+), 1.0mg/ml BSA (IgG, protease free). pH 7.3
Storage	Aliquot and store at -20C or -80C. Avoid repeated freeze / thaw cycles
Restrictions	For research use only

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